Long-term unsupervised mobility assessment in movement disorders
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The development of immune checkpoint inhibitors (ICIs) has revolutionized cancer therapy but only a fraction of patients benefits from this therapy. Model-informed drug development can be used to assess prognostic and predictive clinical factors or biomark ...
Over the years, clinical institutes accumulated large amounts of digital slides from resected tissue specimens. These digital images, called whole slide images (WSIs), are high-resolution tissue snapshots that depict the complex interaction of cells at the ...
H3K27M-mutant diffuse midline glioma (DMG) patients have no proven effective therapies. ONC201 has recently demonstrated efficacy in these patients, but the mechanism behind this remains unknown. We assessed clinical outcomes, tumor sequencing, and tissue/ ...
The drive to develop cartilage implants for the treatment of major defects in the musculoskeletal sys-tem has resulted in a major research thrust towards developing biomaterial devices for cartilage repair. Investigational devices for the restoration of ar ...
Synthetic biology aims to engineer cells as miniature biological devices to sense, process, and respond to exogenous stimuli. Protein switches are designed to sense and respond to various molecular queues in a fast and specific manner, which fits the requi ...
The goal of retinoblastoma (RB) treatment is to save the child's life, eyes and functional vision, with that order of priority. The management of RB is complex and involves strategically chosen methods of surgical enucleation, external beam radiotherapy, i ...
Using artificial intelligence to improve patient care is a cutting-edge methodology, but its implementation in clinical routine has been limited due to significant concerns about understanding its behavior. One major barrier is the explainability dilemma a ...
The increasing implementation of programs supported by machine learning in medical contexts will affect psychiatry. It is crucial to accompany this development with careful ethical considerations informed by empirical research involving experts from the fi ...
BACKGROUND. Clinical Decision Support Systems (CDSS) are point-of-care questionnaires that guide consultations to evidence-based predictions with the aim of standardizing care and optimizing resource allocation. The data collected in these tools contain po ...
Objectives: The precise location of multiple sclerosis (MS) cortical lesions can be very challenging at 3 T, yet distinguishing them from subcortical lesions is essential for the diagnosis and prognosis of the disease. Compressed sensing-accelerated fluid ...