Publication

Surface engineering of T cells with polymer nanoparticles to enhance drug delivery to the brain

Publications associées (50)

Bidirectional Transfer Study of Polystyrene Nanoparticles across the Placental Barrier in an ex Vivo Human Placental Perfusion Model

BACKGROUND: Nanoparticle exposure in utero might not be a major concern yet, but it could become more important with the increasing application of nanomaterials in consumer and medical products. Several epidemiologic and invitro studies have shown that nan ...

Nat Inst of Environ Health Sciences / The National Institute of Environmental Health Sciences (NIEHS)2015

Ultra-sensitive time-resolved infrared spectroscopy of biomolecule interactions with plasmonic nanoantennas

Hatice Altug

We demonstrate a plasmonically enhanced infrared spectroscopy technology that enables in-situ and real-time measurements of protein and nano particle interactions at ultra-high sensitivity by overcoming fundamental water absorption limitations. (C) 2014 Op ...

IEEE2014

Effects of Surface Compositional and Structural Heterogeneity on Nanoparticle-Protein Interactions: Different Protein Configurations

Francesco Stellacci, Randy Patrick Carney

As nanoparticles (NPs) enter into biological systems, they are immediately exposed to a variety and concentration of proteins. The physicochemical interactions between proteins and NPs are influenced by the surface properties of the NPs. To identify the ef ...

American Chemical Society2014

Nanoscale Topography and Chemistry Affect Embryonic Stem Cell Self-Renewal and Early Differentiation

Francesco Stellacci

Adherent cells respond to a wide range of substrate cues, including chemistry, topography, hydrophobicity, and surface energy. The cell-substrate interface is therefore an important design parameter in regenerative medicine and tissue engineering applicati ...

Wiley-Blackwell2013

Surface charge of polymer coated SPIONs influences the serum protein adsorption, colloidal stability and subsequent cell interaction in vitro

Alke Fink, Marc Moniatte

It is known that the nanoparticle-cell interaction strongly depends on the physicochemical properties of the investigated particles. In addition, medium density and viscosity influence the colloidal behaviour of nanoparticles. Here, we show how nanoparticl ...

Royal Soc Chemistry2013

Gold nanoparticles protected by fluorinated ligands for F-19 MRI

Francesco Stellacci

Gold nanoparticles coated with fluorinated ligands (F-MPCs) present features suitable for F-19 MRI as observed from phantom experiments. Cellular uptake, by HeLa cells, and toxicity of fluorescent dye-decorated F-MPCs are presented together with their abil ...

Royal Society of Chemistry2013

Dynamic Cellular Uptake of Mixed-Monolayer Protected Nanoparticles

Francesco Stellacci, Randy Patrick Carney, Tamara Michael Carney, Marie Mueller

Nanoparticles (NPs) are gaining increasing attention for potential application in medicine; consequently, studying their interaction with cells is of central importance. We found that both ligand arrangement and composition on gold nanoparticles play a cru ...

American Vacuum Society2012

Microtechnologies to Map the Fate of Single Stem Cells and their Progeny

Stefan Kobel

Since stem cells have the unique ability to produce more of themselves (i.e. to "self-renew") and to generate specialized tissue cells, they are an ideal source of cells for regenerative medicine and in vitro tissue models. In order to fully exploit this p ...

EPFL2012

Size- and Coating-Dependent Uptake of Polymer-Coated Gold Nanoparticles in Primary Human Dermal Microvascular Endothelial Cells

Harm-Anton Klok, Matthew Gibson

A library-orientated approach is used to gain understanding of the interactions of well-defined nanoparticles with primary human endothelial cells, which are a key component of the vasculature. Fifteen sequentially modified gold nanoparticles (AuNPs) based ...

2012

Surface Modification with Alginate-Derived Polymers for Stable, Protein-Repellent, Long-Circulating Gold Nanoparticles

Anu Kodiyan

Poly(ethylene) glycol is commonly used to stabilize gold nanoparticles (GNPs). In this study, we evaluated the ability of cysteine-functionalized alginate-derived polymers to both provide colloidal stability to GNPs and avoid recognition and sequestration ...

2012

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