Effect of fibre orientation and bulk modulus on the electromechanical modelling of human ventricles
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We consider the numerical simulation of integrated heart models for the study of the cardiac functioning with particular emphasis on the coupling of the muscle contraction, the fluid dynamics of the left ventricle, and the interaction with the valves. We a ...
Oxidative damage of telomeres can promote cancer, cardiac failure, and muscular dystrophy. Specific mechanisms protecting telomeres from oxidative damage have not been described. We analyzed telomeric chromatin composition during the cell cycle and show th ...
Hydrocontest is a student competition involving teams from different universities around Switzerland and the world. This projects aims at providing an analysis of the performances of hydrofoils by means of computational fluid dynamics in a High Performance ...
In this paper, we propose a semi-implicit approach for the time discretization of the Navier–Stokes equations with Variational Multiscale-Large Eddy Simulation turbulence modeling (VMS-LES). For the spatial approximation of the problem, we use the Finite E ...
The aim of this work is the development of a geometrical multiscale framework for the simulation of the human cardiovascular system under either physiological or pathological conditions. More precisely, we devise numerical algorithms for the partitioned so ...
In this project we numerically simulate electrophysiological models for cardiac applications by means of Isogeometric Analysis. Specifically, we aim at understanding the advantages of using high order continuous NURBS (Non-UniformRational B-Splines) basis ...
Background-For reasons that remain unclear, whether type 5 adenylyl cyclase (AC5), 1 of 2 major AC isoforms in heart, is protective or deleterious in response to cardiac stress is controversial. To reconcile this controversy we examined the cardiomyopathy ...
Pluripotent stem cell-seeded cardiopatches hold promise for in situ regeneration of infarcted hearts. Here, we describe a novel cardiopatch based on bone morphogenetic protein 2-primed cardiac-committed mouse embryonic stem cells, embedded into biodegradab ...
An active strain formulation for orthotropic constitutive laws arising in cardiac mechanics modeling is introduced and studied. The passive mechanical properties of the tissue are described by the Holzapfel-Ogden relation. In the active strain formulation, ...
The purpose of this project is to perform topology optimization on the cantilever beam problem, which is a particular case of the two-dimensional elasticity problem. Based on a finite element discretization, a Matlab implementation of the elasticity proble ...