Serotonergic neurons signal reward and punishment on multiple timescales
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Recent experiments have shown that spike-timing-dependent plasticity is influenced by neuromodulation. We derive theoretical conditions for successful learning of reward-related behavior for a large class of learning rules where Hebbian synaptic plasticity ...
While Parkinson's disease has been described nearly 200 years ago, the mechanisms leading to the degeneration of selectively vulnerable populations of neurons, such as dopaminergic neurons in the substantia nigra, remain mostly unknown. Our poor understand ...
Mitochondrial dysfunction and oxidative stress have been implicated in the etiology of Parkinsons disease. Therefore, pathways controlling mitochondrial activity rapidly emerge as potential therapeutic targets. Here, we explore the neuronal response to pro ...
Prediction markets and other reward mechanisms based on proper scoring rules can elicit accurate predictions about future events with public utcomes. However, many questions of public interest do not always have a clear answer. For example, facts such as t ...
We provide upper and lower bounds on the escape rate of the Bhattacharyya process corresponding to polar codes where transmission takes place over the the binary erasure channel. More precisely, we bound the exponent of the number of sub-channels whose Bha ...
This study is part of a long term study on a male rat model of peripubertal stress in the Laboratory of Behavioural Genetics that shows increase aggressive behaviours against their partners. We are using here these rats in order to create a female rat mode ...
We propose a mechanism for providing the incentives for reporting truthful feedback in a peer-to-peer system for exchanging services (or content). This mechanism is to complement reputation mechanisms that employ ratings' feedback on the various transactio ...
Parkinson's disease (PD) is characterized by loss of dopaminergic neurons in the substantia nigra (SN), the cause of which is unknown. Characterization of early SN pathology could prove beneficial in the treatment and diagnosis of PD. The present study sho ...
The recent spate of neuroimaging studies on decision-making under uncertainty has provided converging evidence of a spatio-temporal dissociation of risk and expected reward encoding in the human brain. While this research has demonstrated widespread hemody ...
Dysfunction of the central dopaminergic system is associated with neurodegenerative disorders and mental illnesses such as Parkinson's disease and schizophrenia. Patients suffering from these diseases were reported to exhibit altered immune functions compa ...