Publication
Reference Maps of Human ES and iPS Cell Variation Enable High-Throughput Characterization of Pluripotent Cell Lines
Publications associées (151)
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Mammalian genomes are a battleground for genetic conflict between repetitive elements and KRAB-zinc finger proteins (KZFPs). We asked whether KZFPs can regulate cell fate by using ZFP819, which targets a satellite DNA array, ZP3AR. ZP3AR coats megabase reg ...
2022Molecular profiling of stem cell-derived retinal pigment epithelial cell differentiation established for clinical translation
Gioele La Manno, Alex Russell Lederer, Irina Khven
Human embryonic stem cell-derived retinal pigment epithelial cells (hESC-RPE) are a promising cell source to treat age-related macular degeneration (AMD). Despite several ongoing clinical studies, a detailed mapping of transient cellular states during in v ...
CELL PRESS2022Explicit Stabilized Multirate Method For Stiff Stochastic Differential Equations
Assyr Abdulle, Giacomo Rosilho De Souza
Stabilized explicit methods are particularly efficient, for large systems of stiff stochastic differential equations (SDEs) due to their extended stability domain. However, they lose their efficiency when a severe stiffness is induced by very few "fast" de ...
SIAM PUBLICATIONS2022Z-REX uncovers a bifurcation in function of Keap1 paralogs
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Studying electrophile signaling is marred by difficulties in parsing changes in pathway flux attributable to on-target, vis-& agrave;-vis off-target, modifications. By combining bolus dosing, knockdown, and Z- REX & mdash;a tool investigating on- target/on ...
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Elisa Oricchio, Daniele Tavernari, Stephanie Jocelyne Sungalee, Giovanni Ciriello, Marco Mina
Chromatin compartmentalization reflects biological activity. However, inference of chromatin sub-compartments and compartment domains from chromosome conformation capture (Hi-C) experiments is limited by data resolution. As a result, these have been charac ...
NATURE RESEARCH2021Sensing serotonin secreted from human serotonergic neurons using aptamer-modified nanopipettes
Nako Nakatsuka, Dmitry Momotenko
The serotonergic system in the human brain modulates several physiological processes, and altered serotonergic neurotransmission has been implicated in the neuropathology of several psychiatric disorders. The study of serotonergic neurotransmission in psyc ...
2021Characterization of the ERK1/2 phosphorylation profile in human and fish liver cells upon exposure to chemicals of environmental concern
Kristin Schirmer, Jelena Petrovic
We developed phospho-ERK1/2 ELISA for human and rainbow trout liver cells, employing HepG2 and RTL-W1 cell lines as models. The assay was applied to detect changes in ERK1/2 activity for nine chemicals, added over a wide concentration range and time points ...
ELSEVIER2021Endothelial extracellular vesicles contain protective proteins and rescue ischemia-reperfusion injury in a human heart-on-chip
Maartje Martina Cornelia Bastings
Extracellular vesicles (EVs) derived from various stem cell sources induce cardioprotective effects during ischemia-reperfusion injury (IRI). These have been attributed mainly to the antiapoptotic, proangiogenic, microRNA (miRNA) cargo within the stem cell ...
AMER ASSOC ADVANCEMENT SCIENCE2020A single-cell-based identification and characterisation of Aregs, an inhibitory subpopulation of adipose stem and precursor cells
Adipose tissue is an essential element in energy conservation mechanisms. Its unique plasticity is driven by the ability of adipocytes to accumulate and liberate lipids as a function of the energetic status of the organism. Given the recent rise in the glo ...
EPFL2020Primate-restricted KRAB zinc finger proteins and target retrotransposons control gene expression in human neurons
Didier Trono, Bart Deplancke, Priscilla Turelli, Christian Axel Wandall Thorball, Julien Léonard Duc, Charlène Mireille Raymonde Raclot, Alexandre Coudray, Julien Paul André Pontis, Delphine Yvette L Grun, Christopher James Playfoot, Evgeniia Pankevich
In the first days of embryogenesis, transposable element-embedded regulatory sequences (TEeRS) are silenced by Kruppel-associated box (KRAB) zinc finger proteins (KZFPs). Many TEeRS are subsequently co-opted in transcription networks, but how KZFPs influen ...
2020