Publications associées à The relevance of the artery of Adamkiewicz for microsurgical resection of spinal tumors- short overview and case series: Technical note

Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons

Grégoire Courtine, Jordan Squair, Claudia Kathe, Yi Ding

After spinal cord injury, tissue distal to the lesion contains undamaged cells that could support or augment recovery. Targeting these cells requires a clearer understanding of their injury responses and capacity for repair. Here, we use single nucleus RNA ...

NATURE PORTFOLIO2022

Longitudinal interrogation of sympathetic neural circuits and hemodynamics in preclinical models

Grégoire Courtine, Quentin Barraud, Jordan Squair, Matthieu Pierre Gautier, Rémi Bernard René Hudelle, Suje Amir, Victor Perez Puchalt, Loïs Thomas Romain Mahe, Jan Elaine Cuevas Soriano

Neurological disorders, including spinal cord injury, result in hemodynamic instability due to the disruption of supraspinal projections to the sympathetic circuits located in the spinal cord. We recently developed a preclinical model that allows the ident ...

NATURE PORTFOLIO2022

Natural and targeted circuit reorganization after spinal cord injury

Grégoire Courtine, Jocelyne Bloch, Quentin Barraud, Jordan Squair, Mark Andrew Anderson, Claudia Kathe, Matthieu Pierre Gautier, Thomas Haynes Hutson

The authors summarize changes in circuits after spinal cord injury and current strategies to target these circuits in order to improve recovery, but also advocate for new concepts of reorganizing circuits informed by multi-omic single-cell atlases. A spina ...

NATURE PORTFOLIO2022

Elezanumab, a human anti-RGMa monoclonal antibody, promotes neuroprotection, neuroplasticity, and neurorecovery following a thoracic hemicompression spinal cord injury in non-human primates

Grégoire Courtine, Quentin Barraud, Lili Huang, Xiaomeng Zhang

Spinal cord injury (SCI) is a devastating condition characterized by loss of function, secondary to damaged spinal neurons, disrupted axonal connections, and myelin loss. Spontaneous recovery is limited, and there are no approved pharmaceutical treatments ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2021

Engineering spinal cord repair

Grégoire Courtine, Jordan Squair, Mark Andrew Anderson, Matthieu Pierre Gautier, Michael V. Sofroniew

Neurological damage caused by spinal cord injury in humans has been observed for over three thousand years and impacts the lives of several hundred thousand people worldwide. Despite this prevalence and its associated consequences, there is no treatment to ...

CURRENT BIOLOGY LTD2021

Soft multimodal neural interfaces for unravelling sensory neurological circuits

Frédéric Pierre Gérald Michoud

Diseases or injuries affecting the nervous system can dramatically disrupt the quality of life. Despite extensive efforts towards treating dysfunctional nervous systems, the pharmacological and electrical approaches generally involved lack the temporal and ...

EPFL2019

Neuroprosthetic Technologies to Evaluate and Train Leg Motor Control in Neurologically Impaired Individuals

Camille Georgette Marie Le Goff-Mignardot

Spinal cord injury (SCI) disrupts many essential sensorimotor and autonomic functions. Consequently, individuals with SCI can face decades with permanent disabilities. Advances in clinical management have decreased morbidity, but no clinical trial has yet ...

EPFL2019

Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models

Grégoire Courtine, Quentin Barraud, Claudia Kathe, Thomas Haynes Hutson, Kay Alexander Bartholdi

After a spinal cord injury, axons fail to regenerate in the adult mammalian central nervous system, leading to permanent deficits in sensory and motor functions. Increasing neuronal activity after an injury using electrical stimulation or rehabilitation ca ...

AMER ASSOC ADVANCEMENT SCIENCE2019

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The relevance of the artery of Adamkiewicz for microsurgical resection of spinal tumors- short overview and case series: Technical note

Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons

Longitudinal interrogation of sympathetic neural circuits and hemodynamics in preclinical models

Natural and targeted circuit reorganization after spinal cord injury

Personalizable computational models of electrical spinal cord stimulation to restore function after neurological disorders

Electrical spinal cord stimulation protocols to regulate motor and autonomic functions in people with neurological disorders

Elezanumab, a human anti-RGMa monoclonal antibody, promotes neuroprotection, neuroplasticity, and neurorecovery following a thoracic hemicompression spinal cord injury in non-human primates

Engineering spinal cord repair

Soft multimodal neural interfaces for unravelling sensory neurological circuits

Neuroprosthetic Technologies to Evaluate and Train Leg Motor Control in Neurologically Impaired Individuals

Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models

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Chattez avec Graph Search

Personalizable computational models of electrical spinal cord stimulation to restore function after neurological disorders

Electrical spinal cord stimulation protocols to regulate motor and autonomic functions in people with neurological disorders

Elezanumab, a human anti-RGMa monoclonal antibody, promotes neuroprotection, neuroplasticity, and neurorecovery following a thoracic hemicompression spinal cord injury in non-human primates

Soft multimodal neural interfaces for unravelling sensory neurological circuits

Cbp-dependent histone acetylation mediates axon regeneration induced by environmental enrichment in rodent spinal cord injury models

Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons

Longitudinal interrogation of sympathetic neural circuits and hemodynamics in preclinical models

Natural and targeted circuit reorganization after spinal cord injury

Engineering spinal cord repair

Neuroprosthetic Technologies to Evaluate and Train Leg Motor Control in Neurologically Impaired Individuals