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Obesity Impairs Short-Term and Working Memory through Gut Microbial Metabolism of Aromatic Amino Acids

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Obesity-associated deficits in inhibitory control are phenocopied to mice through gut microbiota changes in one-carbon and aromatic amino acids metabolic pathways

Xavier Fernandez-Real Girona

Background Inhibitory control (IC) is critical to keep long-term goals in everyday life. Bidirectional relationships between IC deficits and obesity are behind unhealthy eating and physical exercise habits. Methods We studied gut microbiome composition and ...

BMJ PUBLISHING GROUP2021

There are important individual differences in adaptation and reactivity to stressful challenges. Being subjected to strict social confinement is a distressful psychological experience leading to reduced emotional well-being, but it is not known how it can ...

2021

Previous studies have shown that the gene encoding the adhesion G protein-coupled receptor L3 (ADGRL3; formerly latrophilin 3, LPHN3) is associated with Attention-Deficit/Hyperactivity Disorder (ADHD). Conversely, no studies have investigated the anatomica ...

2021

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Perceptual decisions are biased towards previous stimuli, a phenomenon known as serial dependence. However, the mechanisms of this bias are unknown. For example, it is debated whether serial dependence reflects a perceptual bias or interference of prior st ...

SAGE Publishing2021

The study investigates how transcranial direct current stimulation (tDCS) over the auditory cortex (AC) modulates memory for melodies under different noise conditions, whilst also considering cumulative disruptive interference effects. Forty-one participan ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2021

From Learning to Memory: A Comparison Between Verbal and Non-verbal Skills in 22q11.2 Deletion Syndrome

Maude Schneider, Karin Bortolin

Background: Previous studies on possible memory deficits in 22q11DS often focused on quantifying the information memorized, whereas learning processes have been mostly overlooked. Furthermore, methodological differences in task design have made verbal and ...

FRONTIERS MEDIA SA2021

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Human pose forecasting involves complex spatiotemporal interactions between body parts (e.g., arms, legs, spine). State-of-the-art approaches use Long Short-Term Memories (LSTMs) or Variational AutoEncoders (VAEs) to solve the problem. Yet, they do not eff ...

IEEE2021

Molecular physiology of bile acid signaling in health, disease, and aging

Kristina Schoonjans, Alessia Perino, Hadrien Charles Edouard Demagny, Laura Alejandra Velazquez Villegas

Over the last two decades, bile acids (BAs) have become established as important signaling molecules that enable fine-tuned inter-tissue communication from the liver, their site of production, over the intestine, where they are modified by the gut microbio ...

2021

Autophagy as a Gatekeeper of Intestinal Homeostasis

Bruno Lemaitre, Xiaoxue Li

The control of gut homeostasis by autophagy in the context of host-microbiota relationship remains poorly understood. In this issue of Developmental Cell, Nagai et al. (2021) show that autophagy plays a crucial role in enterocytes to prevent the mis-regula ...

CELL PRESS2021

Human commensal gut Proteobacteria withstand type VI secretion attacks through immunity protein-independent mechanisms

Melanie Blokesch, Sandrine Stutzmann, Candice Stoudmann, Leonardo Filipe Lemos Rocha, Nicolas Olmo Flaugnatti, Nina Vesel, Sandrine Natacha Isaac, Thibault Géry L Sana

While the major virulence factors for Vibrio cholerae, the cause of the devastating diarrheal disease cholera, have been extensively studied, the initial intestinal colonization of the bacterium is not well understood because non-human adult animals are re ...

2021