Publication
Structures of three MORN repeat proteins and a re-evaluation of the proposed lipid-binding properties of MORN repeats
Publications associées (39)
Connecting vesicular transport with lipid synthesis: FAPP2
Next to the protein-based machineries composed of small G-proteins, coat complexes, SNAREs and tethering factors, the lipid-based machineries are emerging as important players in membrane trafficking. As a component of these machineries, lipid transfer pro ...
2012Phage Pierces the Host Cell Membrane with the Iron-Loaded Spike
Petr Leiman, Christopher Browning
Bacteriophages with contractile tails and the bacterial type VI secretion system have been proposed to use a special protein to create an opening in the host cell membrane during infection. These proteins have a modular architecture but invariably contain ...
2012A Biochemical and Biophysical Investigation of 5-HT3 Receptor Stability
The 5-hydroxytryptamine 3 receptor (5-HT3R) is a member of the pentameric ligand-gated ion channel (pLGIC) family, that plays an important role in fast signal transduction and cell-cell communication in synapses: They convert a chemical signal from a neuro ...
EPFL2012Structural basis for chirality and directional motility of Plasmodium sporozoites
Plasmodium sporozoites can move at high speed for several tens of minutes, which is essential for the initial stage of a malaria infection. The crescent-shaped sporozoites move on 2D substrates preferably in the same direction on circular paths giving rais ...
Wiley-Blackwell2012Bridging across length scales: Multi-scale ordering of supported lipid bilayers via lipoprotein self-assembly and surface patterning
We show that a two-step process, involving spontaneous self-assembly of lipids and apolipoproteins and surface patterning, produces single, supported lipid bilayers over two discrete and independently adjustable length scales. Specifically, an aqueous phas ...
American Chemical Society (ACS)2008Analysis of expression of PDCP and MAL13P1.308 of Plasmodium falciparum employing a quantitative proteomics approach based on SILAC
Plasmodium falciparum is a deadly parasite that causes malaria in humans. This disease causes the death of one million people every year. To find new means to fight this parasite, it is important to learn more about its biology. As the pathways of protein ...
2008Lipid-transfer proteins in biosynthetic pathways
Compartmentalization is a defining feature of eukaryotic cells that allows the spatial segregation of different functions, such as protein and lipid synthesis, and ensures their fidelity and efficiency. This imposes the need for an intense flux of metaboli ...
2008Lipid-transfer proteins in membrane trafficking at the Golgi complex
The Golgi complex (GC) represents the central junction for membrane trafficking. Protein and lipid cargoes continuously move through the GC in both anterograde and retrograde directions, departing to and arriving from diverse destinations within the cell. ...
2007The role of the phosphoinositides at the Golgi complex
Eukaryotic cells are organized into a complex system of subcompartments, each with its distinct protein and lipid composition. A continuous flux of membranes crosses these compartments, and in some cases direct connections exist between the different organ ...
2007Lipid membranes for the fabrication of functional micro- and nano-structures
The central goal of this thesis work is to fabricate novel, functional fluorescent nanostructures in confined systems offered by phospholipid membranes, which are known to have highly ordered, thermotropic and lyotropic structures. In separate approaches, ...
EPFL2006