Publication
Hypoxia Conditioning as a Promising Therapeutic Target in Parkinson's Disease?
Publications associées (34)
Early Neuroprotective Effects of Bovine Lactoferrin Associated with Hypothermia after Neonatal Brain Hypoxia-Ischemia in Rats
Neonatal hypoxic-ischemic (HI) encephalopathy (HIE) in term newborns is a leading cause of mortality and chronic disability. Hypothermia (HT) is the only clinically available therapeutic intervention; however, its neuroprotective effects are limited. Lacto ...
Basel2023Surprise and novelty in the brain
Wulfram Gerstner, Johanni Michael Brea, Alireza Modirshanechi, Sophia Becker
Notions of surprise and novelty have been used in various experimental and theoretical studies across multiple brain areas and species. However, 'surprise' and 'novelty' refer to different quantities in different studies, which raises concerns about whethe ...
CURRENT BIOLOGY LTD2023Interrelation between cardiac and brain small-vessel disease: a pilot quantitative PET and MRI study
Bénédicte Marie Maréchal, Ricardo Alberto Corredor Jerez
Background: Small-vessel disease (SVD) plays a crucial role in cardiac and brain ischemia, but little is known about potential interrelation between both. We retrospectively evaluated 370 patients, aiming at assessing the interrelation between cardiac and ...
London2023Fronto-Temporal Disconnection Within the Presence Hallucination Network in Psychotic Patients With Passivity Experiences
Olaf Blanke, Alessandra Griffa, Jevita Potheegadoo, Patric Hagmann, Kim Do, Nathan Quentin Faivre, Roy Salomon, Giulio Rognini, Eva Blondiaux, Giedre Stripeikyte, Pierre Progin
Psychosis, characterized by hallucinations and delusions, is a common feature of psychiatric disease, especially schizophrenia. One prominent theory posits that psychosis is driven by abnormal sensorimotor predictions leading to the misattribution of self- ...
2021Hallucination Engineering: From Neuroscience Robotics to Hallucinations in Health and Disease
My thesis focuses on a psychotic symptom called the presence hallucination (PH). PHs are defined as the false perception that someone is nearby when no one is actually present. PHs can occur in various populations, ranging from healthy subjects (when expos ...
EPFL2020Gene replacement therapy provides benefit in an adult mouse model of Leigh syndrome
Mutations in nuclear-encoded mitochondrial genes are responsible for a broad spectrum of disorders among which Leigh syndrome is the most common in infancy. No effective therapies are available for this severe disease mainly because of the limited capabili ...
2020Dynamic organization of human brain function and its relevance for psychosis vulnerability
The brain is the substrate of a complex dynamic system providing a remarkably varied range of functionalities, going from simple perception to higher-level cognition. Disturbances in its complex dynamics can cause an equally vast variety of mental disorder ...
EPFL2019Brain networks and their relevance for stroke rehabilitation
Friedhelm Christoph Hummel, Philipp Johannes Koch
Stroke has long been regarded as focal disease with circumscribed damage leading to neurological deficits. However, advances in methods for assessing the human brain and in statistics have enabled new tools for the examination of the consequences of stroke ...
2019Mild Neonatal Brain Hypoxia-Ischemia in Very Immature Rats Causes Long-Term Behavioral and Cerebellar Abnormalities at Adulthood
Hongxia Lei, Yohan Van de Looij
Systemic hypoxia-ischemia (HI) often occurs during preterm birth in human. HI induces injuries to hinder brain cells mainly in the ipsilateral forebrain structures. Such HI injuries may cause lifelong disturbances in the distant regions, such as the contra ...
2019Stress Impacts the Regulation Neuropeptides in the Rat Hippocampus and Prefrontal Cortex
Gregor Rainer, Laura Lozano Montes, Nan Zhao
Adverse life experience increases the lifetime risk to several stress-related psychopathologies, such as anxiety or depressive–like symptom following stress in adulthood. However, the neurochemical modulations triggered by stress have not been fully charac ...
2018