Publication

Controlling the immobilization process of an optically enhanced protein microarray for highly reproducible immunoassay

Publications associées (33)

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Detailed Jet Dynamics in a Collapsing Bubble

Mohamed Farhat, Danail Obreschkow, Philipp Kobel, Outi Supponen

We present detailed visualizations of the micro-jet forming inside an aspherically collapsing cavitation bubble near a free surface. The high-quality visualizations of large and strongly deformed bubbles disclose so far unseen features of the dynamics insi ...

Institute of Physics2015

Microfluidic devices for diagnostic applications

Christoph Merten

Microfluidic systems have become an attractive platform for diagnostic applications. The technology not only allows drastically decreased assay volumes (down to picoliters), but also accelerates sample processing and readout. In this article we give an ove ...

2014

A numerical study of droplet trapping in microfluidic devices

François Gallaire, Pierre-Thomas Paul Brun, Mathias Nagel

Microfluidic channels are powerful means of control of minute volumes such as droplets. These droplets are usually conveyed at will in an externally imposed flow which follows the geometry of the micro-channel. It has recently been pointed out by Dangla et ...

Amer Inst Physics2014

Antibody microarrays are powerful and high-throughput tools for screening and identifying tumor markers from small sample volumes of only a few microliters. Optimization of surface chemistry and spotting conditions are crucial parameters to enhance antibod ...

Amer Chemical Soc2013

Extremely sensitive protein detection is crucial for early diagnosis and monitoring of diseases. Present day’s limit of detection for an antibody-antigen recognition-based immunoassay in serum without having to use special target antigen amplification tech ...

EPFL2012

Micro-segmented flow (e.g. in microfluidic channels, capillaries or a length of tubing) has become a promising technique in modern biology. Compared to conventional formats such as microtiter plates, sample volumes can be reduced about 1000-fold, thus allo ...

2012

Fragmentation of DNA in a sub-microliter microfluidic sonication device

Christoph Merten

Fragmentation of DNA is an essential step for many biological applications including the preparation of next-generation sequencing (NGS) libraries. As sequencing technologies push the limits towards single cell and single molecule resolution, it is of grea ...

2012

UV-Curable Glue (NOA81) for Fabrication of a Closed Microfluidic Channel with Hydrophilic and Hydrophobic Surfaces

Nico de Rooij, Philip Wägli

Polymers like PDMS or SU-8 have become popular for microfluidic applications. We show that modifications of the surface energy are more stable on NOA81 compared to PDMS. A simple method to fabricate a closed all-polymer microfluidic channel showing both hy ...

2011

The physiological properties of cells are typically investigated in ensembles yielding averaged data that mask heterogeneities present in any cell population. Single-cell analysis techniques based on microfluidic "lab on a chip" (LOC) devices have recently ...

EPFL2011

DNA technologies such as cloning, DNA microarrays, and next generation sequencing have transformed the life sciences. Protein technologies on the other hand have not seen such explosive progress. This is mainly due to the inherent difficulty of working wit ...

Elsevier2011