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NREM sleep stages specifically alter dynamical integration of large-scale brain networks

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The transition from wakefulness to sleep represents the most conspicuous change in behavior and the level of consciousness occurring in the healthy brain. It is accompanied by similarly conspicuous changes in neural dynamics, traditionally exemplified by t ...

Oxford University Press2014

Dual orexin receptor antagonists - promising agents in the treatment of sleep disorders

Damien Lapray

Insomnia is a serious medical and social problem, its prevalence in the general population ranges from 9 to 35% depending on the country and assessment method. Often, patients are subject to inappropriate and therefore dangerous pharmacotherapies that incl ...

Cambridge Univ Press2014

Wireless Neurosensor for Full-Spectrum Electrophysiology Recordings during Free Behavior

Grégoire Courtine, Hao Li, David Allenson Borton, Yao Lu, Jean François Pierre Laurens

Brain recordings in large animal models and humans typically rely on a tethered connection, which has restricted the spectrum of accessible experimental and clinical applications. To overcome this limitation, we have engineered a compact, lightweight, high ...

Cell Press2014

Endogenous rhythms of circalunar periodicity (similar to 29.5 days) and their underlying molecular and genetic basis have been demonstrated in a number of marine species [1, 2]. In contrast, there is a great deal of folklore but no consistent association o ...

Elsevier2013

Principal component structuring of the Non-REM sleep EEG spectrum in older adults yields age-related changes in the sleep and wake drives

Mirjam Münch

Age-related disturbances of the sleep-wake cycle can reflect ontogenetic changes in regulatory mechanisms underlying normal and pathological aging, but the exact nature of these changes remains unclear. The present report is the first attempt to apply prin ...

2013

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Sleep wake cycle is characterized by changes in neuronal network activity. However, for the last decade there is increasing evidence that neuroglial interaction may play a role in the modulation of sleep homeostasis and that astrocytes have a critical impa ...

Elsevier2013

Genes Involved in the Astrocyte-Neuron Lactate Shuttle (ANLS) Are Specifically Regulated in Cortical Astrocytes Following Sleep Deprivation in Mice

Pierre Magistretti, Jean-Luc Martin, Jean-Marie Petit, Joël Gyger, Sophie Burlet Godinot

Study Objectives: There is growing evidence indicating that in order to meet the neuronal energy demands, astrocytes provide lactate as an energy substrate for neurons through a mechanism called "astrocyte-neuron lactate shuttle" (ANLS). Since neuronal act ...

American Academy of Sleep Medicine2013

Sleep paralyses are viewed as pure motor phenomena featured by a dissociated state in which REM-related muscle atonia coexists with a wakefulness state of full consciousness. We present a 59-year-old man diagnosed with narcolepsy experiencing sleep paralys ...

2012

Objectives: The close relationship between major depression and sleep disturbances led to the hypothesis of a deficiency in homeostatic sleep pressure in depression (S-deficiency hypothesis). Many observed changes of sleep characteristics in depression are ...

Elsevier2012

Key electrophysiological, molecular, and metabolic signatures of sleep and wakefulness revealed in primary cortical cultures

Johan Auwerx, Richardus Houtkooper, Cyril Mikhail

Although sleep is defined as a behavioral state, at the cortical level sleep has local and use-dependent features suggesting that it is a property of neuronal assemblies requiring sleep in function of the activation experienced during prior wakefulness. He ...

Soc Neuroscience2012