Publication
The Role of Conserved Residues in the DEDDh Motif: the Proton-Transfer Mechanism of HIV-1 RNase H
Publications associées (38)
Proton Transfer Studied Using a Combined Ab Initio Reactive Potential Energy Surface with Quantum Path Integral Methodology
The rates of intramolecular proton transfer are calculated on a full-dimensional reactive electronic potential energy surface that incorporates high-level ab initio calculations along the reaction path and by using classical transition state theory, path-i ...
2010Proton-Coupled Oxygen Reduction at Liquid-Liquid Interfaces Catalyzed by Cobalt Porphine
Hubert Girault, Manuel Alejandro Méndez Agudelo, Fengping Li, Imren Hatay, Zdenek Samec
Cobalt porphine (CoP) dissolved in the organic phase of a biphasic system is used to catalyze O2 reduction by an electron donor, ferrocene (Fc). Using voltammetry at the interface between two immiscible electrolyte solutions (ITIES), it is possible to driv ...
2009Kinetics of the solvent-free hydrogenation of 2-methyl-3-butyn-2-ol over a structured Pd-based catalyst
Albert Renken, Lioubov Kiwi, Rocio Micaela Crespo Quesada, Martin Grasemann
The solvent-free selective hydrogenation of 2-methyl-3-butyn-2-ol (MBY) to 2-methyl-3-buten-2-ol (MBE) was studied over a Pd/ZnO structured catalyst and compared to its behavior in water-assisted conditions. The catalytic behavior was correlated with the s ...
2009Phosphodiester Cleavage in Ribonuclease H Occurs via an Associative Two-Metal-Aided Catalytic Mechanism
Ribonuclease H (RNase H) belongs to the nucleotidyl-transferase (NT) superfamily and hydrolyzes the phosphodiester linkages that form the backbone of the RNA strand in RNA x DNA hybrids. This enzyme is implicated in replication initiation and DNA topology ...
2008Proton shuttles and phosphatase activity in soluble epoxide hydrolase
Recently, a novel metal Mg2+-dependent phosphatase activity has been discovered in the N-terminal domain of the soluble epoxide hydrolase (sEH), opening a new branch of fatty acid metabolism and providing an additional site for drug targeting. Importantly, ...
2007Study of N2O decomposition over Fe-ZSM-5 with transient methods
Nitrous oxide is the third most important gas contributing to global warming and its concentration in the atmosphere is still on the rise. Nitric acid production represents the largest source of N2O in the chemical industry, with a total annual emission of ...
EPFL2007Tools to study molecules in high electric fields
This thesis describes the application of the quantum mechanics/molecular mechanics (QM/MM) Car-Parrinello methodology to two systems of high biological interest: (a) The potassium channel KcsA from Streptomyces lividans and (b) The DNA repair enzyme EndoIV ...
EPFL2006Optimized methods for the enzymatic ligation of oligoribonucleotides and analogues
The preparation of oligoribonucleotides is of great interest for structural and functional investigations in biomolecular chemistry and biology. Relevant RNAs are relatively long and contain often modifications. Two methods for their preparation are curren ...
EPFL2006Switching the Mechanism of Catalyst Activation by Ionic Liquids
Paul Joseph Dyson, Corinne Daguenet
In ionic liqs. (ILs), the activation of a ruthenium(II) catalyst precursor occurs via an unexpected mechanism, which is different from the activation mechanism that takes place in water. The effectiveness of a biphasic catalytic hydrogenation reaction usin ...
2006Similarities and differences of polyadenylation signals in human and fly
ABSTRACT: BACKGROUND: Cleavage of messenger RNA (mRNA) precursors is an essential step in mRNA maturation. The signal recognized by the cleavage enzyme complex has been characterized as an A rich region upstream of the cleavage site containing a motif with ...
2006