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The effect of left ventricular contractility on arterial hemodynamics: A model-based investigation

Publications associées (78)

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Modeling the effects of dispersion and pulsatility of blood flow in pulsed arterial spin labeling

Daniel Gallichan

Arterial spin labeling (ASL) is a method of using MRI to image cerebral perfusion. For the measurement to be calibrated, a model is required describing the kinetics of the flow of the inverted blood from the labeling region to the imaging region. It is com ...

Wiley-Blackwell2008

Effects of an aging vascular model on healthy and diseased hearts

Nikolaos Stergiopoulos, Rafaela Fernandes Da Silva, David Jegger, Patrick Segers

The vitamin D(3) and nicotine (VDN) model is a model of isolated systolic hypertension (ISH) due to arterial calcification raising arterial stiffness and vascular impedance similar to an aged and stiffened arterial tree. We therefore analyzed the impact of ...

2007

Arterial remodeling in response to hypertension using a constituent-based model

Nikolaos Stergiopoulos, Alkiviadis Tsamis

Hypertension-induced arterial remodeling has been previously modeled using stress-driven remodeling rate equations in terms of global geometrical adaptation (Rachev A, Stergiopulos N, Meister JJ. Theoretical study of dynamics of arterial wall remodeling in ...

2007

Effects of a stiffened arterial tree on ventricular-arterial coupling in healthy and diseased hearts

David Jegger

In this thesis we study ventricular-arterial coupling in rodents under the influence of arterial stiffening and myocardial infarction (MI), combination of the two considered as a novel cardiovascular research model for diseased hearts pumping against an ag ...

EPFL2006

The peroxisome proliferator-activated receptor-alpha (PPARalpha) plays a major role in the control of cardiac energy metabolism. The role of PPARalpha on cardiac functions was evaluated by using PPARalpha knockout (PPARalpha -/-) mice. Hemodynamic paramete ...

2006

We investigated the quantitative contribution of all local conduit arterial, blood, and distal load properties to the pressure transfer function from brachial artery to aorta. The model was based on anatomical data, Young's modulus, wall viscosity, blood v ...

2006

Plaque-prone hemodynamics impair endothelial function in pig carotid arteries

Nikolaos Stergiopoulos, Sylvain Roy, Paolo Silacci, Veronica Gambillara

Hemodynamic forces play an active role in vascular pathologies, particularly in relation to the localization of atherosclerotic lesions. It has been established that low shear stress combined with cyclic reversal of flow direction (oscillatory shear stress ...

2006

Effect of intimal shear and cyclic strech on arterial segments perfused in vitro

Veronica Gambillara

Hemodynamics have crucial role in the control of vascular tone, in the regulation of arterial remodeling, and in the production of mediators that maintain arterial function. Changes in hemodynamics forces induce profound alterations in vascular cell metabo ...

EPFL2005

Vascular remodeling is defined as any enduring change in the size and composition of an adult blood vessel, allowing adaptation or repair. The vascular remodeling response has been shown to depend on a variety of endogenous and environmental factors. Physi ...

EPFL2004

Geometrical, functional, and histomorphometric adaptation of rat carotid artery in induced hypertension

Nikolaos Stergiopoulos, Martin Zulliger

Acute and long-term (up to 56 days) evolution of geometry, structural properties, vascular smooth muscle (VSM) tone and histomorphometric properties of the rat common carotid arteries under induced hypertension were investigated. Hypertension was induced i ...

2003