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A secreted factor NimrodB4 promotes the elimination of apoptotic corpses by phagocytes in Drosophila

Publications associées (33)

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The use of tractable model organisms such as Drosophila melanogaster and the powerful genetic tools they offer has contributed significantly to recent advances in comprehension of innate immunity, notably phagocytosis. To date, several phagocytic transmemb ...

EPFL2022

Brain functionality relies on the neuronal-glial-vascular (NGV) ensemble for energy support. However, the details of the complex biological mechanisms involved in these processes and the microscopic interactions between these three components are not yet f ...

EPFL2021

Role of Nimrod receptors in the Drosophila melanogaster cellular immune response

Claudia Melcarne

The use of modern molecular biology tools and simple but powerful tractable model organisms such as Drosophila has contributed significantly to our recent advances in the innate immunity field, notably phagocytosis. Since 2001, many phagocytic transmembran ...

EPFL2020

Transport and programmed release of nanoscale cargo from cells by using NETosis

Ardemis Anoush Boghossian, Alice Judith Gillen, Alessandra Antonucci, Daniel Meyer

Cells can take up nanoscale materials, which has important implications for understanding cellular functions, biocompatibility as well as biomedical applications. Controlled uptake, transport and triggered release of nanoscale cargo is one of the great cha ...

ROYAL SOC CHEMISTRY2020

Cryogenic Infrared Action Spectroscopy Fingerprints the Hydrogen Bonding Network in Gas-Phase Coumarin Cations

Thomas Rizzo, Robert Paul Pellegrinelli, Eduardo Carrascosa Casado

We report cryogenic vibrational spectra of gas-phase cations of two common hydroxycoumarins, scopoletin and esculetin, as well as their glycosidic derivatives, scopolin and esculin. The study allows direct observation of the intramolecular interactions bet ...

AMER CHEMICAL SOC2020

The Transcription Factor Nfix Requires RhoA-ROCK1 Dependent Phagocytosis to Mediate Macrophage Skewing during Skeletal Muscle Regeneration

Giuliana Rossi

Macrophages (MPs) are immune cells which are crucial for tissue repair. In skeletal muscle regeneration, pro-inflammatory cells first infiltrate to promote myogenic cell proliferation, then they switch into an anti-inflammatory phenotype to sustain myogeni ...

2020

We present an analysis of the structure, kinematics, and orbit of a newly found stellar stream emanating from the globular cluster M92 (NGC 6341). This stream was discovered in an improved matched-filter map of the outer Galaxy, based on a "color-color-mag ...

IOP PUBLISHING LTD2020

Phagocytosis in Drosophila: From molecules and cellular machinery to physiology

Bruno Lemaitre, Claudia Melcarne

Phagocytosis is an evolutionarily conserved mechanism that plays a key role in both host defence and tissue homeostasis in multicellular organisms. A range of surface receptors expressed on different cell types allow discriminating between self and non-sel ...

PERGAMON-ELSEVIER SCIENCE LTD2019

Two Nimrod receptors, NimC1 and Eater, synergistically contribute to bacterial phagocytosis in Drosophila melanogaster

Bruno Lemaitre, Jan Paul Dudzic, Elodie Julie Virginie Ramond, Andrew Jonathan Bretscher, Claudia Melcarne

Eater and NimC1 are transmembrane receptors of the Drosophila Nimrod family, specifically expressed in haemocytes, the insect blood cells. Previous ex vivo and in vivoRNAi studies have pointed to their role in the phagocytosis of bacteria. Here, we have cr ...

WILEY2019

Both calculated quantities in the paper, fractal dimension and lacunarity respectively, prove high precision as foreteller to classify the glial cells tissue in various brain morphologies. The importance of microglia in neurodegenerative diseases and the i ...

UNIV POLITEHNICA BUCHAREST, SCI BULL2019