Publication
Gene-by-environment modulation of lifespan and weight gain in the murine BXD family
Publications associées (41)
Identifying genetic and dietary modulators of metabolic disorders using systems genetics
Long-term consumption of lipid-rich foods can contribute to common metabolic diseases and systemic low-grade inflammation. However, dietary responses and the development of non-communicable diseases are shaped by genetic factors and gene-by-environment int ...
EPFL2023The interplay between human genetic variation, chronic inflammation and persistent infection: relevance for cardiovascular morbidity
Contemporary genomic approaches allow us to seek answers to biological questions that were previously out of reach. Genome-wide association studies (GWAS) have identified numerous genetic polymorphisms associated with human diseases, providing new insight ...
EPFL2022Population structure and signals of local adaptation in Eugenia uniflora (Myrtaceae), a widely distributed species in the Atlantic Forest
Evolutionary diversity in species can arise in many ways, including local adaptation. Despite the global importance of tropical forest ecosystems, few studies have explored patterns of local adaptation in tropical tree species. We investigated population g ...
OXFORD UNIV PRESS2022The effects of time-restricted eating and weight loss on bone metabolism and health: a 6-month randomized controlled trial
Nicholas Edward Phillips, Alexandra Hemmer
Objective This study explored the impact of time-restricted eating (TRE) versus standard dietary advice (SDA) on bone health. Methods Adults with >= 1 component of metabolic syndrome were randomized to TRE (ad libitum eating within 12 hours) or SDA (food p ...
WILEY2022Proteomics reveals unique plasma signatures in constitutional thinness
Loïc Dayon, Jörg Hager, Nele Gheldof
Purpose Studying the plasma proteome of control versus constitutionally thin (CT) individuals, exposed to overfeeding, may give insights into weight-gain management, providing relevant information to the clinical entity of weight-gain resistant CT, and dis ...
WILEY-V C H VERLAG GMBH2022The role and transcriptional regulation of FAM46A in adipocyte differentiation
Obesity is currently a leading global health concern. Treatments include undergoing a weight-loss regimen. However, successful weight-loss is variable, where the heritability of obesity is considered part of the cause. This patient variability to weight-lo ...
EPFL2021Toward a mechanistic understanding of variable chromatin modules
Our genome is a long sequence of DNA that contains all the information to be able to constitute a living organism like us, similarly to what the letters in a book do to create a story. This sequence, which is a stretch of molecules called nucleotides, is a ...
EPFL2021Genetic signatures of divergent selection in European beech (Fagus sylvatica L.) are associated with the variation in temperature and precipitation across its distribution range
High genetic variation and extensive gene flow may help forest trees with adapting to ongoing climate change, yet the genetic bases underlying their adaptive potential remain largely unknown. We investigated range-wide patterns of potentially adaptive gene ...
WILEY2021Genetic variation near CXCL12 is associated with susceptibility to HIV-related non-Hodgkin lymphoma
Jacques Fellay, Christian Axel Wandall Thorball, Christian Hammer
Human immunodeficiency virus (HIV) infection is associated with an increased risk of non-Hodgkin lymphoma (NHL). Even in the era of suppressive antiretroviral treatment, HIV-infected individuals remain at higher risk of developing NHL compared to the gener ...
FERRATA STORTI FOUNDATION2021The genetic architecture of complex human traits at the dawn of genomic medicine
The focus of the work presented in this thesis is the exploration of the genetic architecture of complex human traits - at the dawn of genomic medicine.
The underlying mechanisms explaining the enormously polygenic nature of most human complex traits are ...
EPFL2021