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FTLD-TDP assemblies seed neoaggregates with subtype-specific features via a prion-like cascade

Publications associées (32)

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The Silent Period of Evidence Integration in Fast Decision Making

Michael Herzog, Wulfram Gerstner, Johannes Rüter

In a typical experiment on decision making, one out of two possible stimuli is displayed and observers decide which one was presented. Recently, Stanford and colleagues (2010) introduced a new variant of this classical one-stimulus presentation paradigm to ...

Public Library of Science2013

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It has been more than a century since the first evidence linking the process of amyloid formation to the pathogenesis of Alzheimer's disease. During the last three decades in particular, increasing evidence from various sources (pathology, genetics, cell c ...

Elsevier2012

During mild heat-stress, a native thermolabile polypeptide may partially unfold and transiently expose water-avoiding hydrophobic segments that readily tend to associate into a stable misfolded species, rich in intra-molecular non-native beta-sheet structu ...

2011

Motivated by the ongoing investigation of SrCu2(BO3)(2) under pressure, we study a variant of the two-dimensional Shastry-Sutherland (SS) spin-1/2 model with two types of dimers. Combined with the frustration of the SS model, this modification induces, in ...

2011

Impact of phosphorylation of alpha-synuclein in Parkinson's disease

Samareh Azeredo da Silveira Lajaunias

Parkinson's disease (PD) is characterized by the degeneration of dopamineric neurons of the substantia nigra pars compacta projecting to the striatum, and by the deposition of cytoplasmic protein inclusions. It is further defined by the persistent presence ...

EPFL2008

Bistability of protein aggregation as a function of molecular chaperone concentration

Vassily Hatzimanikatis

Cells are constantly subjected to stresses; these stresses take the form of heat, heavy metals, metabolic poisons, non-native peptides, and many others. All of these stresses have the potential to cause protein misfolding, which drives protein aggregation. ...

2005

Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease

Hilal Lashuel

Parkinson's disease (PD) is a neurologic disorder resulting from the loss of dopaminergic neurons in the brain. Two lines of evidence suggest that the protein alpha-synuclein plays a role in the pathogenesis of PD: Fibrillar alpha-synuclein is a major comp ...

Humana Press2004

Spectroscopic and dc-transport investigations of the electronic properties of TaSe3

László Forró, Marco Grioni, Helmuth Berger, Neven Barisic

TaSe3 belongs to a class of low-dimensional materials characterized by the interplay and competition between dimensionality crossover and broken symmetry ground states. A comprehensive study by dc-transport, optical, and angle-resolved photoemission (ARPES ...

Springer Verlag2004

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Cross-correlated fluctuations of isotropic chem. shifts can provide evidence for slow motions in biomols. Slow side-chain dynamics have been investigated in 15N and 13C enriched ubiquitin by monitoring the relaxation of Ca-Cb two-spin coherences (Frueh et ...

Springer, Kluwer Academic Publishers2004

Evidence of Slow Motions by Cross-Correlated Chemical Shift Modulation in Deuterated and Protonated Proteins

Geoffrey Bodenhausen, Julien Wist, Chiara Perazzolo

2004