Publication
Antiviral drug resistance as an adaptive process
Publications associées (32)
PSGL-1 is an evolutionarily conserved antiviral restriction factor
The arms race between viruses and their hosts shaped the evolutionary history and the genome composition of both parties. Restriction factors are the first-line antiviral effectors encoded by the host genomes and are often conserved through evolution to pr ...
AMER SOC MICROBIOLOGY2023Ligand concentration determines antiviral efficacy of silica multivalent nanoparticles
Francesco Stellacci, Paulo Henrique Jacob Silva, Quy Ong Khac, Xufeng Xu, Rémi Andréa La Polla, Heyun Wang
We have learned from the recent COVID-19 pandemic that the emergence of a new virus can quickly become a global health burden and kill millions of lives. Antiviral drugs are essential in our fight against viral diseases, but most of them are virus-specific ...
San Diego2023The SNP-Based Profiling of Montecristo Feral Goat Populations Reveals a History of Isolation, Bottlenecks, and the Effects of Management
The Montecristo wild goat is an endangered feral population that has been on the homonymous island in the Tuscan Archipelago since ancient times. The origins of Montecristo goats are still debated, with authors dating their introduction either back to Neol ...
MDPI2022Highly Potent Host-Specific Small-Molecule Inhibitor of Paramyxovirus and Pneumovirus Replication with High Resistance Barrier
Gerardo Turcatti, Marc Chambon, Damiano Banfi, Jonathan Patrice Vesin
Multiple enveloped RNA viruses of the family Paramyxoviridae and Pneumoviridae, like measles virus (MeV), Nipah virus (NiV), canine distemper virus (CDV), or respiratory syncytial virus (RSV), are of high clinical relevance. Each year a huge number of live ...
AMER SOC MICROBIOLOGY2021The population genetics of crypsis in vertebrates: recent insights from mice, hares, and lizards
Jeffrey David Jensen, Susanne Petra Pfeifer, Stefan Jean Laurent
By combining well-established population genetic theory with high-throughput sequencing data from natural populations, major strides have recently been made in understanding how, why, and when vertebrate populations evolve crypsis. Here, we focus on backgr ...
NATURE PUBLISHING GROUP2020Limits on amplifiers of natural selection under death-Birth updating
The fixation probability of a single mutant invading a population of residents is among the most widely-studied quantities in evolutionary dynamics. Amplifiers of natural selection are population structures that increase the fixation probability of advanta ...
PUBLIC LIBRARY SCIENCE2020A high-content image-based drug screen of clinical compounds against cell transmission of adenovirus
Gerardo Turcatti, Fabien Kuttler
Human adenoviruses (HAdVs) are fatal to immuno-suppressed individuals, but no effective anti-HAdV therapy is available. Here, we present a novel image-based high-throughput screening (HTS) platform, which scores the full viral replication cycle from virus ...
2020The Combined Effect of Oseltamivir and Favipiravir on Influenza A Virus Evolution
Jeffrey David Jensen, Claudia Bank, Sebastian Matuszewski, Nicky Louise Ormond
Influenza virus inflicts a heavy death toll annually and resistance to existing antiviral drugs has generated interest in the development of agents with novel mechanisms of action. Favipiravir is an antiviral drug that acts by increasing the genome-wide mu ...
Oxford University Press (OUP)2017The Demographic and Adaptive History of the African Green Monkey
Relatively little is known about the evolutionary history of the African green monkey (genus Chlorocebus) due to the lack of sampled polymorphism data fromwild populations. Yet, this characterization of genetic diversity is not only critical for a better u ...
Oxford Univ Press2017Viral genetic variation accounts for a third of variability in HIV-1 set-point viral load in Europe
HIV-1 set-point viral load-the approximately stable value of viraemia in the first years of chronic infection-is a strong predictor of clinical outcome and is highly variable across infected individuals. To better understand HIV-1 pathogenesis and the evol ...
Public Library Science2017