Publication
The cGAS–STING pathway drives type I IFN immunopathology in COVID-19
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Heterochromatin loss and genetic instability enhance cancer progression by favoring clonal diversity, yet uncontrolled replicative stress leads to mitotic catastrophe and inflammatory responses that promote immune rejection. KRAB domain-containing zinc fin ...
2024Type I IFNs link skin-associated dysbiotic commensal bacteria to pathogenic inflammation and angiogenesis in rosacea
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Rosacea is a common chronic inflammatory skin disease with a fluctuating course of excessive inflammation and apparent neovascularization. Microbial dysbiosis with a high density of Bacillus oleronius and increased activity of kallikrein 5, which cleaves c ...
AMER SOC CLINICAL INVESTIGATION INC2023Clathrin-associated AP-1 control stermination of STING signalling
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Stimulator of interferon genes (STING) functions downstream of cyclic GMP-AMP synthase in DNA sensing or as a direct receptor for bacterial cyclic dinucleotides and small molecules to activate immunity during infection, cancer and immunotherapy(1-10). Prec ...
NATURE PORTFOLIO2022Cell-autonomous inflammation of BRCA1-deficient ovarian cancers drives both tumor-intrinsic immunoreactivity and immune resistance via STING
George Coukos, Julien Dorier, Christian Iseli, Mauro Delorenzi, Alizée Jéléna Grimm, Giovanni Ciriello, Alexandre Harari, Marco Mina
In this study, we investigate mechanisms leading to inflammation and immunoreactivity in ovarian tumors with homologous recombination deficiency (HRD). BRCA1 loss is found to lead to transcriptional reprogramming in tumor cells and cell-intrinsic inflammat ...
2021m6A methylation potentiates cytosolic dsDNA recognition in a sequence-specific manner
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Nucleic acid sensing through pattern recognition receptors is critical for immune recognition of microbial infections. Microbial DNA is frequently methylated at the N-6 position of adenines (m6A), a modification that is rare in mammalian host DNA. We show ...
ROYAL SOC2021Adjuvant-free immunization with infective filarial larvae as lymphatic homing antigen carriers
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Controlled infection with intestinal nematodes has therapeutic potential for preventing the symptoms of allergic and autoimmune diseases. Here, we engineered larvae of the filarial nematode Litomosoides sigmodontis as a vaccine strategy to induce adaptive ...
NATURE PUBLISHING GROUP2020cGAS regulation and activity during genotoxic stress
The innate immune system has evolved to detect pathogens through germlineencoded
pattern recognition receptors (PRRs). Nucleic acid sensors, a defined class
of PRRs, bind to microbial and viral nucleic acids and trigger the production of type
I interferons ...
EPFL2020Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
Jacques Fellay, Rui Yang, Jie Chen, Yu Zhang, Xavier Duval, Peng Zhang, Qian Zhang, Zhiyong Liu, Juan Li
Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19). We have found an enrichment in rare variants predicted to be loss-of-function (LOF ...
AMER ASSOC ADVANCEMENT SCIENCE2020House dust mite drives proinflammatory eicosanoid reprogramming and macrophage effector functions
Nicola Harris, Julia Esser-von Bieren, Tiffany Babette Angélique Bouchery
Background Eicosanoid lipid mediators play key roles in type 2 immune responses, for example in allergy and asthma. Macrophages represent major producers of eicosanoids and they are key effector cells of type 2 immunity. We aimed to comprehensively track e ...
WILEY2019Mitochondrial stress signalling and its impacts on physiology
Adrienne Joëlle Laurence Mottis
Mitochondria are responsible for respiration and energy harvesting across the eukaryotic kingdom. They also take part in other cellular processes like intermediary metabolism. As a result, mitochondrial function directly impacts organismal features such as ...
EPFL2018