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Effect of minor amounts of beta-calcium pyrophosphate and hydroxyapatite on the physico-chemical properties and osteoclastic resorption of beta-tricalcium phosphate cylinders

Publications associées (26)

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The role of MYC in bone and in the hematopoietic stem cell niche

Maike Jaworski

The nuclear protein c-Myc is one of the most potent proto-oncogenes described. Its expression is found to be deregulated in more than 50 percent of human cancers, where it has been shown to control a number of biological processes including driving prolife ...

EPFL2009

3D model of bone remodeling coupled with a drug effect

Philippe Abdel Sayed

Total hip replacement, which is a successful solution for restoring movement to damaged joints, becomes nowadays a common surgical procedure. However the lifespan of hip implants is limited, because of pathologic strain distribution in bone inducing bone-r ...

2009

Human fetal bone cells associated with ceramic reinforced PLA scaffolds for tissue engineering

Dominique Pioletti, Pierre-Etienne Bourban, Corinne Scaletta, Claire Diane Delabarde

Fetal bone cells were shown to have an interesting potential for therapeutic use in bone tissue engineering due to their rapid growth rate and their ability to differentiate into mature osteoblasts in vitro. We describe hereafter their capability to promot ...

2008

Microstimulations at the bone implant interface upregulate osteoclast activation pathway

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann

Peri-implant bone resorption after total joint arthroplasty is a key parameter in aseptic loosening. Implant wear debris and biomechanical aspects have both been demonstrated to be part of the bone resorption process. However, neither of these two paramete ...

2008

Notch receptors are determinants of cell fate decisions. To define the role of Notch in the adult skeleton, we created transgenic mice overexpressing the Notch intracellular domain (NICD) under the control of the type I collagen promoter. First generation ...

2008

Implants delivering bisphosphonate locally increase periprosthetic bone density in an osteoporotic sheep model. A pilot study

Dominique Pioletti, Alexandre Terrier, Vincent Stadelmann

It is a clinical challenge to obtain a sufficient orthopedic implant fixation in weak osteoporotic bone. When the primary implant fixation is poor, micromotions occur at the bone-implant interface, activating osteoclasts, which leads to implant loosening. ...

2008

Fetal bone cells for tissue engineering

In this thesis, the potential use of fetal bone cells for tissue engineering was evaluated. At first, fetal bone cells were characterized in vitro regarding their proliferation rate, the induction of their osteoblastic phenotype, and their antigenicity. Th ...

EPFL2007

Synthetic bone substitutes are potentially the future gold standard in orthopaedic and traumatologic surgery. The availability of these bone substitutes with different biomechanical properties may well replace autografts in the future as they overcome comp ...

EPFL2007

In an attempt to increase the life of cementless prostheses, an hydroxyapatite-coated implant which releases a bisphosphonate has been suggested as a drug-delivery system. Our in vitro study was designed to determine the maximum dose to which osteoblasts c ...

2005

Orthopedic implants used as drug delivery systems

Bastian Peter

Total Hip Replacement (THR) is today a routine procedure executed more than 800'000 times per year worldwide. THR gives generally satisfactory results, although the quality of outcome is inversely proportional to the age of the patient. In parallel, there ...

EPFL2004