Lateralising value of experiential hallucinations in temporal lobe epilepsy

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Signatures of life course socioeconomic conditions in brain anatomy

Maria del Carmen Sandi Perez, Bogdan Draganski

Socioeconomic status (SES) plays a significant role in health and disease. At the same time, early-life conditions affect neural function and structure, suggesting the brain may be a conduit for the biological embedding of SES. Here, we investigate the bra ...

Wiley2022

Brain-wide screen of prelimbic cortex inputs reveals a functional shift during early fear memory consolidation

Johannes Gräff, Lucie Pauline Dixsaut

Memory formation and storage rely on multiple interconnected brain areas, the contribution of which varies during memory consolidation. The medial prefrontal cortex, in particular the prelimbic cortex (PL), was traditionally found to be involved in remote ...

2022

Aesthetic experience enhances first-person spatial representation

Mariana Babo Rebelo, Marie Chatel

Episodic autobiographical memories are characterized by a spatial context and an affective component. But how do affective and spatial aspects interact? Does affect modulate the way we encode the spatial context of events? We investigated how one element o ...

National Academy of Sciences2022

Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders

Maria del Carmen Sandi Perez, Ioannis Zalachoras, Sara Ramirez Flores

Obesity and type 2 diabetes are associated with cognitive dysfunction. Because the hypothalamus is implicated in energy balance control and memory disorders, we hypothesized that specific neurons in this brain region are at the interface of metabolism and ...

Cell Press2022

Insights into the interaction of a shale with CO2

Lyesse Laloui, Eleni Stavropoulou

Caprock formations, such as shales, play a key role in safe underground CO2 storage since they serve as a hydromechanical barrier that prevents migration of the injected CO2 to the surface. While their hydromechanical response is important to ensure their ...

2022

An insular cortex - lateral amygdala network in fear learning

Shriya Palchaudhuri

Animals are capable of evaluating sensory cues for possible threats and adapting their behaviours accordingly. Fear learning is an evolutionarily conserved behaviour crucial for animal survival, during which sensory percepts with a negative reinforcing qua ...

EPFL2022

The HDAC inhibitor CI-994 acts as a molecular memory aid by facilitating synaptic and intracellular communication after learning

Johannes Gräff, Giulia Santoni, Allison Marie Burns, Jose Vicente Sanchez Mut

Long-term memory formation relies on synaptic plasticity, neuronal activity-dependent gene transcription, and epigenetic modifications. Multiple studies have shown that HDAC inhibitor (HDACi) treatments can enhance individual aspects of these processes and ...

2022

Epigenetic memory aids: Synaptic and molecular effects of HDAC inhibition that support memory formation

Allison Marie Burns

Learning and memory rely on synaptic communication in which intracellular signals are transported to the nucleus to stimulate transcriptional activation. Memory induced transcriptional increases are accompanied by alterations to the epigenetic landscape an ...

EPFL2022

Disruption of layer-specific visual processing in a model of focal neocortical epilepsy

Silvestro Micera, Matteo Vissani

The epileptic brain is the result of a sequence of events transforming normal neuronal populations into hyperexcitable networks supporting recurrent seizure generation. These modifications are known to induce fundamental alterations of circuit function and ...

OXFORD UNIV PRESS INC2022

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Hypothalamic pregnenolone mediates recognition memory in the context of metabolic disorders

Maria del Carmen Sandi Perez, Ioannis Zalachoras, Sara Ramirez Flores

Cell Press2022

An insular cortex - lateral amygdala network in fear learning

Shriya Palchaudhuri

EPFL2022

The HDAC inhibitor CI-994 acts as a molecular memory aid by facilitating synaptic and intracellular communication after learning

Johannes Gräff, Giulia Santoni, Allison Marie Burns, Jose Vicente Sanchez Mut

2022