Publication
Identification of broad anti-coronavirus chemical agents for repurposing against SARS-CoV-2 and variants of concern
Publications associées (44)
Stability of influenza A virus in droplets and aerosols is heightened by the presence of commensal respiratory bacteria
Athanasios Nenes, Tamar Kohn, Kalliopi Violaki, Ghislain Gilles Jean-Michel Motos, Aline Laetitia Schaub, Shannon Christa David, Walter Hugentobler, Htet Kyi Wynn, Céline Terrettaz, Laura José Costa Henriques, Daniel Scott Nolan, Marta Augugliaro
Aerosol transmission remains a major challenge for control of respiratory viruses, particularly those causing recurrent epidemics, like influenza A virus (IAV). These viruses are rarely expelled alone, but instead are embedded in a consortium of microorgan ...
2024Inactivation of influenza A virus in expiratory droplets and aerosol particles and the associated physicochemical drivers
Influenza is an infectious respiratory illness caused by influenza viruses. Every year, it causes up to one billion cases of disease worldwide. Despite its high disease burden, the transmission pathway of influenza remains subject to debate. There is incre ...
EPFL2024Anti-sars-cov-2 antibodies and use thereof in the treatment of sars-cov-2 infection
Didier Trono, Priscilla Turelli
The disclosure provides antibodies, or antigen-binding fragments thereof, and use thereof in prophylaxis, treatment and/or attenuation of a SARS-CoV-2 virus infection. ...
2024Viral Genetic Determinants of Prolonged Respiratory Syncytial Virus Infection Among Infants in a Healthy Term Birth Cohort
Jacques Fellay, Zhi Ming Xu, Dylan Lawless, Thomas Junier
Background. Respiratory syncytial virus (RSV) is associated with acute respiratory infection. We sought to identify RSV variants associated with prolonged infection. Methods. Among healthy term infants we identified those with prolonged RSV infection and c ...
OXFORD UNIV PRESS INC2023Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range
Didier Trono, Henning Paul-Julius Stahlberg, Priscilla Turelli, Florence Pojer, Dongchun Ni, Sergey Nazarov, Kelvin Ka Ching Lau, Alexander Myasnikov, Emiko Uchikawa
nvestigation of potential hosts of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is crucial to understanding future risks of spillover and spillback. SARS-CoV-2 has been reported to be transmitted from humans to various animals after req ...
2023Aerosol pH is an overlooked driver of airborne influenza and coronavirus inactivation
The current pandemic has added to the growing evidence that respiratory viruses can be transmitted by the airborne route. Non-pharmaceutical interventions, such as mask wearing or ventilation, aim to reduce the public health burden of respiratory diseases ...
2023Ligand concentration determines antiviral efficacy of silica multivalent nanoparticles
Francesco Stellacci, Paulo Henrique Jacob Silva, Quy Ong Khac, Xufeng Xu, Rémi Andréa La Polla, Heyun Wang
We have learned from the recent COVID-19 pandemic that the emergence of a new virus can quickly become a global health burden and kill millions of lives. Antiviral drugs are essential in our fight against viral diseases, but most of them are virus-specific ...
San Diego2023Markers of limbic system damage following SARS-CoV-2 infection
Dimitri Nestor Alice Van De Ville, Alessandra Griffa, Idris Guessous, Alexandre Cionca
Alterations of the limbic system may be present in the chronic phase of SARS-CoV-2 infection. Our aim was to study the long-term impact of this disease on limbic system-related behaviour and its associated brain functional connectivity, according to the se ...
OXFORD UNIV PRESS2023Impact of COVID-19 on long-term lung function in lung transplant recipients: A single-center retrospective cohort study
Available data are limited concerning long-term lung function (LF) evolution after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in lung transplant (LT) recipients. The aim of this study is to determine the effect of first SARS-CoV ...
WILEY2023Expiratory Aerosol pH: The Overlooked Driver of Airborne Virus Inactivation
Athanasios Nenes, Tamar Kohn, Kalliopi Violaki, Ghislain Gilles Jean-Michel Motos, Aline Laetitia Schaub, Shannon Christa David, Walter Hugentobler
Respiratory viruses, including influenza virus and SARS-CoV-2, are transmitted by the airborne route. Air filtration and ventilation mechanically reduce the concentration of airborne viruses and are necessary tools for disease mitigation. However, they ign ...
2022