Publication
Standard-Free Quantification of Dicarboxylic Acids: Case Studies with Salt-Rich Effluents and Serum
Publications associées (100)
Advancing Glycan Analysis: Cryogenic Ion Spectroscopy for Database-Driven Identification
Glycans play a pivotal role in both physiological processes; however, the field of glycobiology remains relatively understudied within biochemistry. The intricate complexity of glycans, coupled with their abundance of isomeric forms, presents formidable ch ...
EPFL2023New Approach for the Identification of Isobaric and Isomeric Metabolites
Thomas Rizzo, Ahmed Ben Faleh, Stephan Warnke, Ali H Abikhodr, Teun Van Wieringen
The structural elucidation of metabolite molecules is important in many branches of the life sciences. However, the isomeric and isobaric complexity of metabolites makes their identification extremely challenging, and analytical standards are often require ...
AMER CHEMICAL SOC2023Identification of Isomeric Biomolecules by Infrared Spectroscopy of Solvent-Tagged Ions
The difference in functionality of many isomeric biomolecules requires their analytical identification for life science studies. We present a universal approach for quantitative identification of different small- to medium-sized isomeric biomolecules that ...
AMER CHEMICAL SOC2022High-frequency gaseous and particulate chemical characterization using extractive electrospray ionization mass spectrometry (Dual-Phase-EESI-TOF)
Andrea Baccarini, Imad El Haddad, Mihnea Surdu, Houssni Lamkaddam
To elucidate the sources and chemical reaction pathways of organic vapors and particulate matter in the ambient atmosphere, real-time detection of both the gas and particle phase is needed. State-of-the-art techniques often suffer from thermal decompositio ...
COPERNICUS GESELLSCHAFT MBH2022Gentle nano-electrospray ion source for reliable and efficient generation of microsolvated ions
Vladimir Kopysov, Andrei Zviagin
We present herein the design of a nano-electrospray ion source capable of reliable generation of large quantities of microsolvated ions. The source is based on a triple molecular skimmer scheme and can be quickly tuned to generate bare ions or their ionic ...
AIP Publishing2022A gas phase approach for glycan analysis: Combining ultrahigh-resolution ion mobility spectrometry with cryogenic vibrational spectroscopy
The last decades have been punctuated by the development of revolutionary analytical technologies that have enabled the analysis of biomolecular structures and unraveled the roles they play in biological systems. However, certain classes of biomolecules re ...
EPFL2021Analyzing glycans cleaved from a biotherapeutic protein using a combination of ion mobility spectrometry and cryogenic ion spectroscopy
The characterization of biomolecules plays a central role in biomedical research. The development of state-of-the-art technologies is needed to make such analyses faster, more sensitive, and more accurate. While mass spectrometry continues to play a centra ...
EPFL2021Charging and ion ejection dynamics of large helium nanodroplets exposed to intense femtosecond soft X-ray pulses
Christoph Bostedt, Camila Bacellar Cases Da Silveira, Daniela Rupp
Ion ejection from charged helium nanodroplets exposed to intense femtosecond soft X-ray pulses is studied by single-pulse ion time-of-flight (TOF) spectroscopy in coincidence with small-angle X-ray scattering. Scattering images encode the droplet size and ...
SPRINGER HEIDELBERG2021Accelerating photofragmentation UV Spectroscopy–Mass spectrometry fingerprinting for quantification of isomeric peptides
Oleg Boyarkine, Elizaveta Solovyeva, Erik Saparbayev
Identification of isomeric biomolecules remains a challenging analytical problem. A recently developed spectroscopic method that combines UV photofragmentation and mass spectrometry for fingerprinting of cold ions (2D UV-MS), has already demonstrated its h ...
2021Molecular characterization of ultrafine particles using extractive electrospray time-of-flight mass spectrometry
Andrea Baccarini, Mihnea Surdu, Lubna Dada, Houssni Lamkaddam
Aerosol particles negatively affect human health while also having climatic relevance due to, for example, their ability to act as cloud condensation nuclei. Ultrafine particles (diameter Dp < 100 nm) typically comprise the largest fraction of the total nu ...
2021