Publication
Sensor-based control strategies for integration of epidural electrical stimulation in rehabilitation after spinal cord injury
Publications associées (78)
Neurorehabilitation and neuroprosthetic technologies to regain motor function following spinal cord injury
Spinal cord injury (SCI) leads to a range of disabilities, including locomotor impairments that seriously diminish the patients’ quality of life. Strategies to promote functional recovery after severe SCI will undoubtedly include approaches to regenerate i ...
ETH Zurich2014Neuroprosthetic rehabilitation and translational mechanism after severe spinal cord injury
Lucia Florinda Friedli Wittler
Traumatic SCIs have long-term health, economic and social consequences, stressing the urgency to develop interventions to improve recovery after such injuries. Today, the only proven effective interventions to enhance recovery after SCI are activity-based ...
EPFL2014Neuroprosthetic system to restore locomotion after neuromotor disorder
Neuromodulation of spinal sensorimotor circuits improves motor control in animal models and humans with Spinal Cord Injury (SCI) and Parkinson disease. Stimulation parameters are tuned manually and remain constant during motor execution which is suboptimal ...
EPFL2014Muscle Spindle Feedback Directs Locomotor Recovery and Circuit Reorganization after Spinal Cord Injury
Grégoire Courtine, Isabel Laura Vollenweider
Spinal cord injuries alter motor function by disconnecting neural circuits above and below the lesion, rendering sensory inputs a primary source of direct external drive to neuronal networks caudal to the injury. Here, we studied mice lacking functional mu ...
Elsevier2014A Computational Model for Epidural Electrical Stimulation of Spinal Sensorimotor Circuits
Silvestro Micera, Grégoire Courtine, Marco Capogrosso, Stanisa Raspopovic, Pavel Musienko, Nikolaus Wenger, Janine Beauparlant
Epidural electrical stimulation (EES) of lumbosacral segments can restore a range of movements after spinal cord injury. However, the mechanisms and neural structures through which EES facilitates movement execution remain unclear. Here, we designed a comp ...
Society for Neuroscience2013Selective Enhancement of Motor Imagery Features Using Transcranial Direct Current Stimulation
José del Rocio Millán Ruiz, Ricardo Andres Chavarriaga Lozano, Robert Leeb, Andrea Biasiucci
Transcranial Direct Current Stimulation (tDCS) has been shown to selectively modulate cortical responses in memory, motor and perceptual tasks. Here we show that this type of stimulation results in targeted enhancement of brain patterns elicited during mot ...
Graz University of Technology Publishing House2013[Neuronal control of posture and locomotion in decerebrated and spinalized animals]
Grégoire Courtine, Pavel Musienko
We have found that the brainstem-spinal cord circuitry of decerebrated cats actively maintain the equilibrium during standing, walking and imposed mechanical perturbations similar to that observed in intact animals. The corrective hindlimb motor responses ...
2013Multisystem Neuroprosthetic Training Improves Bladder Function After Severe Spinal Cord Injury
Grégoire Courtine, Rubia van den Brand, Daniel Eberli
Severe spinal cord injury leads to neurogenic bladder dysfunction. We recently developed a multisystem neuroprosthetic training program that promotes plastic changes capable of restoring refined locomotion in rats with severe spinal cord injury. We investi ...
Elsevier Science Inc2013Versatile robotic interface to evaluate, enable and train locomotion and balance after neuromotor disorders
Grégoire Courtine, Pavel Musienko, Rubia van den Brand, Lucia Florinda Friedli Wittler
Central nervous system (CNS) disorders distinctly impair locomotor pattern generation and balance, but technical limitations prevent independent assessment and rehabilitation of these subfunctions. Here we introduce a versatile robotic interface to evaluat ...
Nature Publishing Group2012Multi-system neurorehabilitative strategies to restore motor functions following severe spinal cord injury
Grégoire Courtine, Pavel Musienko, Rubia van den Brand, Lucia Florinda Friedli Wittler
Severe spinal cord injury (SCI) permanently abolishes motor functions caudal to the lesion. However, the neuronal machinery sufficient to produce standing and stepping is located below most SCI, and can be reactivated with training. Therefore, why do rats ...
2012