Publication
Balancing NAD(+) deficits with nicotinamide riboside: therapeutic possibilities and limitations
Publications associées (32)
Establishment of Reference Intervals of Blood Parameters Among the Healthy Afghan Population
Purpose: This study was designed and conducted to validate the reference values of hematological parameters for healthy adult male and female residents of Kabul city, Afghanistan. Methodology: In this cross-sectional study, the samples were collected accor ...
Albany2024Early-life vitamin A treatment rescues neonatal infection-induced durably impaired tolerogenic properties of celiac lymph nodes
Gut -draining mesenteric and celiac lymph nodes (mLNs and celLNs) critically contribute to peripheral tolerance toward food and microbial antigens by supporting the de novo induction of regulatory T cells (Tregs). These tolerogenic properties of mLNs and c ...
Cell Press2024Flexible Silk-Based Graphene Bioelectronics For Wearable Multimodal Physiological Monitoring
We introduce a skin-inspired epidermal bioelectronic patch (EBP) with unprecedented integration of graphene on silk with a facile and cost-effective fabrication process, excluding complex ink formulation. We advance the state-of-the-art by directly screen- ...
IEEE2023NAD(+) Precursors: A Questionable Redundancy
The last decade has seen a strong proliferation of therapeutic strategies for the treatment of metabolic and age-related diseases based on increasing cellular NAD(+) bioavailability. Among them, the dietary supplementation with NAD(+) precursors-classicall ...
MDPI2022The role of nicotinamide riboside metabolism in pancreatic beta cells
Pancreatic beta cells play a major role in the regulation of glucose homeostasis by secreting insulin in response to elevated blood glucose levels. A gradual deterioration of functional beta cell mass and the chronic elevation of blood glucose levels are c ...
EPFL2022Differential role of nicotinamide adenine dinucleotide deficiency in acute and chronic kidney disease
Johan Auwerx, Elena Katsyuba, Adrienne Joëlle Laurence Mottis, Joseph Rutkowski, Renuga Devi Rajaram
Background. Nicotinamide adenine dinucleotide (NAD(+)) is a ubiquitous coenzyme involved in electron transport and a cosubstrate for sirtuin function. NAD(+) deficiency has been demonstrated in the context of acute kidney injury (AKI). Methods. We studied ...
2021Transient vitamin B5 starving improves mammalian cell homeostasis and protein production
Maintaining a metabolic steady state is essential for an organism's fitness and survival when confronted with environmental stress, and metabolic imbalance can be reversed by exposing the organism to fasting. Here, we attempted to apply this physiological ...
ACADEMIC PRESS INC ELSEVIER SCIENCE2020Development of novel tools for imaging of metabolic fluxes in vivo
Bioluminescent imaging is a powerful technique that enables imaging in living organisms with high sensitivity, low background signal, low cost and without the need for radioactivity. The emitted photons are produced in the oxidation reaction of luciferin c ...
EPFL2020NAD(+) homeostasis in health and disease
Johan Auwerx, Mario Romani, Elena Katsyuba, Dina Hofer
The conceptual evolution of nicotinamide adenine dinucleotide (NAD(+)) from being seen as a simple metabolic cofactor to a pivotal cosubstrate for proteins regulating metabolism and longevity, including the sirtuin family of protein deacylases, has led to ...
NATURE PUBLISHING GROUP2020SLC25A51 is a mammalian mitochondrial NAD(+) transporter
Mitochondria require nicotinamide adenine dinucleotide (NAD(+)) to carry out the fundamental processes that fuel respiration and mediate cellular energy transduction. Mitochondrial NAD(+) transporters have been identified in yeast and plants(1,2), but thei ...
NATURE RESEARCH2020