Publication
De novo developed small cyclic peptides that are orally available
Publications associées (60)
C-Terminal Bioconjugation of Peptides through Photoredox Catalyzed Decarboxylative Alkynylation
Jérôme Waser, Franck Le Vaillant, Marion Marie-Agnès Garreau
We report the first decarboxylative alkynylation of the C-terminus of peptides starting from free carboxylic acids. The reaction is fast, metal-free, and proceeds cleanly to afford alkynylated peptides with a broad tolerance for the C-terminal amino acid. ...
2019Label-free and charge-sensitive dynamic imaging of lipid membrane hydration on millisecond time scales
Sylvie Roke, Orly Bagunu Tarun
Biological membranes are highly dynamic and complex lipid bilayers, responsible for the fate of living cells. To achieve this function, the hydrating environment is crucial. However, membrane imaging typically neglects water, focusing on the insertion of p ...
2018Clustering on Membranes: Fluctuations and More
Clustering of extracellular ligands and proteins on the plasma membrane is required to perform specific cellular functions, such as signaling and endocy- tosis. Attractive forces that originate in perturbations of the membrane’s phys- ical properties contr ...
2018Development of cyclic peptide inhibitors of coagulation factor XII and matrix metalloproteinase 2
Peptides represent a promising molecular class for drug development. They combine several strengths of small molecules (e.g. efficient tissue diffusion, low immunogenicity and access to chemical synthesis) and key properties of biologics such as monoclonal ...
EPFL2018Noncovalent Protein and Peptide Functionalization of Single-Walled Carbon Nanotubes for Biodelivery and Optical Sensing Applications
Ardemis Anoush Boghossian, Alessandra Antonucci, Justyna Kupis-Rozmyslowicz
The exquisite structural and optical characteristics of single-walled carbon nanotubes (SWCNTs), combined with the tunable specificities of proteins and peptides, can be exploited to strongly benefit technologies with applications in fields ranging from bi ...
Amer Chemical Soc2017Elastic and dynamic properties of membrane phase-field models
Phase-field models have been extensively used to study interfacial phenomena, from solidification to vesicle dynamics. In this article, we analyze a phase-field model that captures the relevant physical features that characterize biological membranes. We s ...
Springer2017Development of an albumin-binding ligand for prolonging the plasma half-life of peptide therapeutics
Peptides represent a promising format for the development of therapeutics since they combine the advantages of proteins and small molecules. Several techniques based on rational design or in vitro evolution can be used to develop peptides as therapeutics. ...
EPFL2017New methods for developing (bi)cyclic peptides by phage display
Cyclic peptide ligands are a promising molecular format for the development of therapeutics. They combine some of the advantages of large protein therapeutics (high affinity and specificity) and of small molecule drugs (accessibility to chemical synthesis ...
EPFL2017Site-Specific Polymer Attachment to HR2 Peptide Fusion Inhibitors against HIV-1 Decreases Binding Association Rates and Dissociation Rates Rather Than Binding Affinity
Harm-Anton Klok, Frederik Roman Wurm, Maarten Danial
A popular strategy for overcoming the limited plasma half-life of peptide heptad repeat 2 (HR2) fusion inhibitors against HIV-1 is conjugation with biocompatible polymers such as poly(ethylene glycol) (PEG). However, despite improved resistance to proteoly ...
2017Acylated heptapeptide binds albumin with high affinity and application as tag furnishes long-acting peptides
Christian Heinis, Alessandro Zorzi, Jonas Alfred Karl Wilbs, Simon Jan Middendorp
The rapid renal clearance of peptides in vivo limits this attractive platform for the treatment of a broad range of diseases that require prolonged drug half-lives. An intriguing approach for extending peptide circulation times works through a 'piggy-back' ...
2017