Publication
Combining European and US risk prediction models with polygenic risk scores to refine cardiovascular prevention: the CoLaus|PsyCoLaus Study
Publications associées (36)
Spatial analysis of 10-year predicted risk and incident atherosclerotic cardiovascular disease: the CoLaus cohort
Stéphane Joost, Idris Guessous, David Nicolas De Ridder, Guillaume Jordan
Whether cardiovascular risk scores geographically aggregate and inform on spatial development of atherosclerotic cardiovascular diseases (ASCVD) remains unknown. Our aim is to determine the spatial distribution of 10-year predicted cardiovascular risk and ...
2024Associations of genetic and infectious risk factors with coronary heart disease
Jacques Fellay, Christian Axel Wandall Thorball, Zhi Ming Xu, Flavia Aurelia Shoko Hodel, Roxane De La Harpe
Coronary heart disease (CHD) is one of the most pressing health problems of our time and a major cause of preventable death. CHD results from complex interactions between genetic and environmental factors. Using multiplex serological testing for persistent ...
eLIFE SCIENCES PUBL LTD2023Predicting type 2 diabetes risk before and after solid organ transplantation using polygenic scores in a Danish cohort
Jacques Fellay, Christian Axel Wandall Thorball
Type 2 diabetes mellitus (T2DM) can be multifactorial where both genetics and environmental factors play a role. We aimed to investigate the use of polygenic risk scores (PRS) in the prediction of pre-transplant T2DM and post-transplant diabetes mellitus ( ...
Lausanne2023Impact of facade details on the reliability of performance-based decisions for early-stage neighborhood designs
Neighborhood-scale projects often commence with the conceptualization of several massing-schemes as potential design solutions. There is growing interest in using building performance simulation (BPS) to evaluate and rank such conceptual stage schemes in o ...
EPFL2020Assessing Subaquatic Mass Movement Hazards: an Integrated Observational and Hydrodynamic Modelling Approach
Damien Bouffard, Nathalie Dubois
High-resolution lake and reservoir bathymetric surveys can pinpoint locations that may experience underwater landslides (subaquatic sedimentary mass movements). These can pose a risk to underwater and shoreline infrastructure. This paper outlines an approa ...
2020Tiered Approach to Resilience Assessment
Marie-Valentine Renée Agnès Florin, Aleksandar Jovanovic
Regulatory agencies have long adopted a three-tier framework for risk assessment. We build on this structure to propose a tiered approach for resilience assessment that can be integrated into the existing regulatory processes. Comprehensive approaches to a ...
2018Resilience management during large-scale epidemic outbreaks
Assessing and managing the impact of large-scale epidemics considering only the individual risk and severity of the disease is exceedingly difficult and could be extremely expensive. Economic consequences, infrastructure and service disruption, as well as ...
2018EaRL: Toolbox for Earthquake Risk and Loss Assessment of Building Assets
Dimitrios Lignos, Ahmed Mohamed Ahmed Elkady, Seong-Hoon Hwang
Infrastructure (asset) risk management is essential for a resilient environment. Several industries are concerned to improve their building asset preparedness subject to seismic hazard. To this end, the development of software tools that quantify and asses ...
2018Computational study of the risk of restenosis in coronary bypasses
Alfio Quarteroni, Christian Vergara
Coronary artery disease, caused by the buildup of atherosclerotic plaques in the coronary vessel wall, is one of the leading causes of death in the world. For high-risk patients, coronary artery bypass graft is the preferred treatment. Despite overall exce ...
Springer Heidelberg2017Pesticides drive risk of micropollutants in wastewater-impacted streams during low flow conditions
Micropollutants enter surface waters through various pathways, of which wastewater treatment plants (WWTPs) are a major source. The large diversity of micropollutants and their many modes of toxic action pose a challenge for assessing environmental risks. ...
Pergamon-Elsevier Science Ltd2017