Asymmetric Construction of alpha,alpha-Disubstituted Piperazinones Enabled by Benzilic Amide Rearrangement
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An unprecedent asymmetric catalytic benzilic amide rearrangement for the synthesis of α,α-disubstituted piperazinones is reported. The reaction proceeds via a domino [4+1] imidazolidination/formal 1,2-nitro- gen shift/1,2-aryl or alkyl migration sequence, ...
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