Publication
Overexpression of human alpha-Synuclein leads to dysregulated microbiome/metabolites with ageing in a rat model of Parkinson disease
Publications associées (55)
Organ Neuroprosthetics: Connecting Transplanted and Artificial Organs with the Nervous System
Implantable neural interfaces with the central and peripheral nervous systems are currently used to restore sensory, motor, and cognitive functions in disabled people with very promising results. They have also been used to modulate autonomic activities to ...
Wiley2024Microfluidic systems for infectious disease diagnostics
Microorganisms, encompassing both uni- and multicellular entities, exhibit remarkable diversity as omnipresent life forms in nature. They play a pivotal role by supplying essential components for sustaining biological processes across diverse ecosystems, i ...
Cambridge2024Reconstruction of nerve functional topography using recruitment curves enables selective electrical stimulation
Silvestro Micera, Simone Romeni, Bianca Ziliotto
Multi-polar stimulation protocols have been used in the past to increase the selectivity of electrical stimulation of the nervous system. Nonetheless, the number of possible multipolar stimulation protocols is prohibitively large and cannot be explored dur ...
IEEE2023A method to establish functional vagus nerve topography from electro-neurographic spontaneous activity
Silvestro Micera, Simone Romeni
Bioelectronic medicine is an emerging approach to treat many types of diseases via electrical stimulation of the autonomic nervous system (ANS). Because the vagus nerve (VN) is one of the most important nerves controlling several ANS functions, stimulation ...
2022IL-17 controls central nervous system autoimmunity through the intestinal microbiome
Interleukin-17A- (IL-17A) and IL-17F-producing CD4(+) T helper cells (T(H)17 cells) are implicated in the development of chronic inflammatory diseases, such as multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). T-H 17 ...
AMER ASSOC ADVANCEMENT SCIENCE2021Parkinson mice show functional and molecular changes in the gut long before motoric disease onset
Background: There is increasing evidence that Parkinson's disease (PD) might start in the gut, thus involving and compromising also the enteric nervous system (ENS). At the clinical onset of the disease the majority of dopaminergic neurons in the midbrain ...
BMC2021Simultaneous decoding of cardiovascular and respiratory functional changes from pig intraneural vagus nerve signals
Silvestro Micera, Simone Romeni, Ivo Strauss
Objective. Bioelectronic medicine is opening new perspectives for the treatment of some major chronic diseases through the physical modulation of autonomic nervous system activity. Being the main peripheral route for electrical signals between central nerv ...
IOP PUBLISHING LTD2021Dietary Fiber Is Essential to Maintain Intestinal Size, L-Cell Secretion, and Intestinal Integrity in Mice
Dietary fiber has been linked to improved gut health, yet the mechanisms behind this association remain poorly understood. One proposed mechanism is through its influence on the secretion of gut hormones, including glucagon-like peptide-1 (GLP-1) and gluca ...
FRONTIERS MEDIA SA2021Toxicity and translocation of Ag, CuO, ZnO and TiO2 nanoparticles upon exposure to fish intestinal epithelial cells
Understanding the ability of fish intestinal cells to act as a barrier for nanoparticle (NP) uptake and their effects is of significance from an environmental perspective as well as for human health, for which fish serves as an important nutrient source. W ...
ROYAL SOC CHEMISTRY2021Autophagy as a Gatekeeper of Intestinal Homeostasis
The control of gut homeostasis by autophagy in the context of host-microbiota relationship remains poorly understood. In this issue of Developmental Cell, Nagai et al. (2021) show that autophagy plays a crucial role in enterocytes to prevent the mis-regula ...
CELL PRESS2021