Publications associées à Bioengineering human mini-intestines with in vivo-like complexity and function

Recapitulating macro-scale tissue self-organization through organoid bioprinting

Matthias Lütolf, Moritz Hofer, Mikhail Nikolaev, Jonathan Brassard

A 3D bioprinting approach has been developed to facilitate tissue morphogenesis by directly depositing organoid-forming stem cells in an extracellular matrix, with the ability to generate intestinal epithelia and branched vascular tissue constructs. Biopri ...

NATURE RESEARCH2020

Homeostatic mini-intestines through scaffold-guided organoid morphogenesis

Matthias Lütolf, Nathalie Brandenberg, Yoji Tabata, Nikolche Gjorevski, Mikhail Nikolaev, Nicolas Antoine Vincent Broguiere, Olga Mitrofanova, Devanjali Dutta

Epithelial organoids, such as those derived from stem cells of the intestine, have great potential for modelling tissue and disease biology(1-4). However, the approaches that are used at present to derive these organoids in three-dimensional matrices(5,6)r ...

NATURE PUBLISHING GROUP2020

Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration

Kristina Schoonjans, Alessia Perino, Maroun Bou Sleiman, Giovanni Sorrentino, Ece Yildiz, Gaby El Alam

BACKGROUND & AIMS: Renewal and patterning of the intestinal epithelium is coordinated by intestinal stem cells (ISCs); dietary and metabolic factors provide signals to the niche that control ISC activity. Bile acids (BAs), metabolites in the gut, signal nu ...

2020

The Effect of Thiol Structure on Allyl Sulfide Photodegradable Hydrogels and their Application as a Degradable Scaffold for Organoid Passaging

Matthias Lütolf, Nikolche Gjorevski

Intestinal organoids are useful in vitro models for basic and translational studies aimed at understanding and treating disease. However, their routine culture relies on animal-derived matrices that limit translation to clinical applications. In fact, ther ...

WILEY-V C H VERLAG GMBH2020

Mechano-modulatory synthetic niches for liver organoid derivation

Kristina Schoonjans, Matthias Lütolf, Giovanni Sorrentino, Saba Rezakhani, Ece Yildiz

The recent demonstration that primary cells from the liver can be expanded in vitro as organoids holds enormous promise for regenerative medicine and disease modelling. The use of three-dimensional (3D) cultures based on ill-defined and potentially immunog ...

NATURE PUBLISHING GROUP2020

Low-Defect Thiol-Michael Addition Hydrogels as Matrigel Substitutes for Epithelial Organoid Derivation

Matthias Lütolf, Nikolche Gjorevski, Saba Rezakhani

Due to their selective crosslinking chemistry and well-defined mechano-biochemical characteristics, hydrogels crosslinked by thiol-Michael addition reactions have garnered immense interest for 3D cell culture applications. These hydrogels are typically for ...

2020

Fish-gut-on-chip: development of a microfluidic bioreactor to study the role of the fish intestine in vitro

Philippe Renaud, Kristin Schirmer, Carolin Drieschner

In this study we present the first fish-gut-on-chip model. This model is based on the reconstruction of the intestinal barrier by culturing two intestinal cell lines from rainbow trout, namely epithelial RTgutGC and fibroblastic RTgutF, in an artificial mi ...

2019

Bioinspired Hydrogels for 3D Organoid Culture

Matthias Lütolf, Delphine Lorraine Perle Blondel

Organoids have stepped into the limelight as unique in vitro systems for modeling organ development, function and disease. This review provides a perspective on how chemically defined, bio-inspired hydrogels could be used for replacing ill-defined matrices ...

SWISS CHEMICAL SOC2019

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Bioengineering human mini-intestines with in vivo-like complexity and function

Recapitulating macro-scale tissue self-organization through organoid bioprinting

Homeostatic mini-intestines through scaffold-guided organoid morphogenesis

Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration

The Effect of Thiol Structure on Allyl Sulfide Photodegradable Hydrogels and their Application as a Degradable Scaffold for Organoid Passaging

Mechano-modulatory synthetic niches for liver organoid derivation

Low-Defect Thiol-Michael Addition Hydrogels as Matrigel Substitutes for Epithelial Organoid Derivation

Bioengineering the Human Muscle Stem-Cell Niche for Therapeutic Applications

Fish-gut-on-chip: development of a microfluidic bioreactor to study the role of the fish intestine in vitro

Bioinspired Hydrogels for 3D Organoid Culture

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Chattez avec Graph Search

Bioengineering the Human Muscle Stem-Cell Niche for Therapeutic Applications

Recapitulating macro-scale tissue self-organization through organoid bioprinting

The Effect of Thiol Structure on Allyl Sulfide Photodegradable Hydrogels and their Application as a Degradable Scaffold for Organoid Passaging

Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration

Low-Defect Thiol-Michael Addition Hydrogels as Matrigel Substitutes for Epithelial Organoid Derivation

Mechano-modulatory synthetic niches for liver organoid derivation

Homeostatic mini-intestines through scaffold-guided organoid morphogenesis

Fish-gut-on-chip: development of a microfluidic bioreactor to study the role of the fish intestine in vitro

Bioinspired Hydrogels for 3D Organoid Culture