Pan-cancer atlas of somatic core and linker histone mutations
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Chromatin remodeling through histone posttranslational modifications (PTMs) and DNA methylation has recently been implicated in cognitive functions, but the mechanisms involved in such epigenetic regulation remain poorly understood. Here, we show that prot ...
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Photodynamic therapy (PDT) for cancer in the esophagus and bronchi with red (630 nm) light may occasionally lead to wall perforation and fistula. Therefore, the clin. use of a less penetrating wavelength (514 nm) was investigated for the curative treatment ...
In recent years a substantial body of evidence derived from not only preclinical but also clinical studies has accumulated in support of Notch signaling playing important oncogenic roles in several types of cancer. The finding that activating Notch mutatio ...
We present the first feasibility test of spectromicroscopy on the microlocalization of gadolinium in brain cancer tissue. A gadolinium compound was injected to the patients before the brain tumor was extracted with surgery, and we looked for Gd in the tumo ...
Boron neutron capture therapy (BNCT) is an experimental, binary treatment far brain cancer which requires as the first step that tumor tissue is targeted with a boron-10 containing compound. Subsequent exposure to a thermal neutron flux results in destruct ...
