Publication
Breakdown and rejuvenation of aging brain energy metabolism
Publications associées (35)
Molecular reconstruction and simulation of the Neuron-Glia-Vasculature system
The outstanding information processing capacity of the brain relies on numerous molecular mechanisms. It is an extremely energy-expensive function, which involves specialization and collaboration of different cell types. A common framework to study the com ...
EPFL2023Thermomechanical properties of honeycomb lattices from internal-coordinates potentials: the case of graphene and hexagonal boron nitride
Nicola Marzari, Francesco Libbi
Lattice dynamics in low-dimensional materials and, in particular, the quadratic behaviour of the flexural acoustic modes play a fundamental role in their thermomechanical properties. A first-principles evaluation of these can be very demanding, and can be ...
IOP PUBLISHING LTD2021Mechanistic insights into AMP-activated protein kinase-dependent gene expression
AMP-activated protein kinase (AMPK) is a fundamental enzyme that controls energy homeostasis, through orchestrating the cellular response to a reduction in energy availability. Under conditions of cellular energy stress AMPK senses the decrease in ATP leve ...
EPFL2019Metabolomics reveals tepotinib‐related mitochondrial dysfunction in MET activating mutations‐driven models
Genetic aberrations in the hepatocyte growth factor receptor tyrosine kinase MET induce oncogenic addiction in various types of human cancers, advocating MET as a viable anticancer target. Here, we report that MET signaling plays an important role in confe ...
2019Dynamic Imaging of Lipid Membranes by Means of Water
Lipid membranes are self-assembled structures whose composition determines the properties of membranes of cells and organelles. The molecular level understanding of lipid membranes is based on spectroscopy and MD simulations of lipid monolayer systems. As ...
EPFL2019Nonlinear microscopy for temporally and spatially resolved label-free imaging of living cells
The human brain consists of approximately a hundred billion of neurons that communicate through a unique series of biochemical and electrical processes. When neuronal networks are solicited, electrochemical processes happen involving millions of cells with ...
EPFL2018Membrane water for probing neuronal membrane potentials and ionic fluxes at the single cell level
Pierre Magistretti, Sylvie Roke, Orly Bagunu Tarun, Pascal Jourdain, Marie Eve Pascale Didier
Neurons communicate through electrochemical signaling within a complex network. These signals are composed of changes in membrane potentials and are traditionally measured with the aid of (toxic) fluorescent labels or invasive electrical probes. Here, we d ...
Nature Publishing Group2018Whole-Cell Recording of Neuronal Membrane Potential during Behavior
Neuronal membrane potential is of fundamental importance for the mechanistic understanding of brain function. This review discusses progress in whole-cell patch-clamp recordings for low-noise measurement of neuronal membrane potential in awake behaving ani ...
Cell Press2017Rhythmic and clock-dependent chromatin loops regulate circadian gene expression
In mammals the circadian clock drives daily behavioural and physiological changes that resonate with environmental cues, which can be observed, for example, in the intricate timing of rest during the night and activity during the day in humans. The circadi ...
EPFL2017Aging and sarcopenia associate with specific interactions between gut microbes, serum biomarkers and host physiology in rats
Sonia Karaz, Anirikh Chakrabarti, Mojgan Masoodi, Alice Pannerec, Jay Siddharth
The microbiome has been demonstrated to play an integral role in the maintenance of many aspects of health that are also associated with aging. In order to identify areas of potential exploration and intervention, we simultaneously characterized age-relate ...
Impact Journals Llc2017