Sharpening the blades of the dentate gyrus: how adult-born neurons differentially modulate diverse aspects of hippocampal learning and memory
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Intensive research is devoted to unravel the neurobiological mechanisms mediating adult hippocampal neurogenesis, its regulation by antidepressants, and its behavioral consequences. Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokin ...
The high pressure neurological syndrome develops during deep-diving (> 1.1 MPa) involving impairment of cognitive functions, alteration of synaptic transmission and increased excitability in cortico-hippocampal areas. The medial perforant path (MPP), conne ...
The development of robotic cognition and the advancement of understanding of human cognition form two of the current greatest challenges in robotics and neuroscience, respectively. The RobotCub project aims to develop an embodied robotic child (iCub) with ...
L1 and NCAM, two cell adhesion molecules of the immunoglobulin superfamily, have been implicated in the formation of neural circuits, synaptic plasticity, and cognitive function. In this study, we sought to investigate whether differences in the steady-sta ...
Animals behave in different ways depending on the specific task they are required to solve. In certain cases, if a cue marks the goal location, they can rely on simple stimulusresponse associations. In contrast, other tasks require the animal to be endowed ...
To investigate the function(s) of adult hippocampal neurogenesis, behavioral testing with two different animal models was conducted. The first model utilised transgenic mice expressing a Wnt signalling inhibitor (dnWNT) in the DG to knock-down neurogenesis ...
To understand the interface between global brain function and molecular neuroscience--that is, the microcircuit level--a major challenge. Such understanding is prerequisite if we are to account for neural function in cellular terms. Very few vertebrate mic ...
Notch1 regulates neural stem cell (NSC) number during development, but its role in adult neurogenesis is unclear. We generated nestin-CreER(T2)/R26R-YFP/Notch1(loxP/loxP) [Notch1inducible knock-out (iKO)] mice to allow tamoxifen (TAM)-inducible elimination ...
The cognitive deficits observed in children with cyanotic congenital heart disease suggest involvement of the developing hippocampus. Chronic postnatal hypoxia present during infancy in these children may play a role in these impairments. To understand the ...
In the adult mammalian brain, neural stem cells persist in the subventricular zone and the hippocampus, producing new functional neurons throughout life. Whether and how adult neurogenesis maintains brain function remains highly debated. This question is o ...
