Publication
A common NFKB1 variant detected through antibody analysis in UK Biobank predicts risk of infection and allergy
Publications associées (71)
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Basel2023High-affinity peptides developed against calprotectin and their application as synthetic ligands in diagnostic assays
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A peptide was developed that binds to calprotectin, a marker of major inflammatory disorders, and found to be suited for diagnostic tests. The use of synthetic peptides in assays is of great interest due to their high precision, robustness and low price. C ...
NATURE PORTFOLIO2023The interplay between human genetic variation, chronic inflammation and persistent infection: relevance for cardiovascular morbidity
Contemporary genomic approaches allow us to seek answers to biological questions that were previously out of reach. Genome-wide association studies (GWAS) have identified numerous genetic polymorphisms associated with human diseases, providing new insight ...
EPFL2022Gene expression patterns associated with multidrug therapy in multibacillary leprosy
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Multidrug therapy (MDT) has been successfully used in the treatment of leprosy. However, although patients are cured after the completion of MDT, leprosy reactions, permanent disability, and occasional relapse/reinfection are frequently observed in patient ...
FRONTIERS MEDIA SA2022Phase separation in viral infections
Viruses rely on the reprogramming of cellular processes to enable efficient viral replication; this often requires subcompartmentalization within the host cell. Liquid-liquid phase separation (LLPS) has emerged as a fundamental principle to organize and su ...
ELSEVIER SCI LTD2022The combined impact of persistent infections and human genetic variation on C-reactive protein levels
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Multiple human pathogens establish chronic, sometimes life-long infections. Even if they are often latent, these infections can trigger some degree of local or systemic immune response, resulting in chronic low-grade inflammation. There remains an incomple ...
BMC2022Invasive Streptococcal Infection Can Lead to the Generation of Cross-Strain Opsonic Antibodies
The bacterium Streptococcus pyogenes is a common cause of both mild and severe human diseases resulting in substantial morbidity and mortality each year. No vaccines are available, and our understanding of the antibody response to this human pathogen is st ...
AMER SOC MICROBIOLOGY2022A high-throughput cell- and virus-free assay shows reduced neutralization of SARS-CoV-2 variants by COVID-19 convalescent plasma
Didier Trono, Priscilla Turelli, Florence Pojer, Charlène Mireille Raymonde Raclot, Valeria Cagno, Jérémy Campos, Céline Pellaton
The detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibodies in the serum of an individual indicates previous infection or vaccination. However, it provides limited insight into the protective nature of this immune resp ...
AMER ASSOC ADVANCEMENT SCIENCE2021Immunological lessons from genome-wide association studies of infections
Jacques Fellay, Christian Axel Wandall Thorball, Alessandro Borghesi
Over the past few years, genome-wide association studies (GWAS) have been increasingly applied to identify host genetic factors influencing clinical and laboratory traits related to immunity and infection, and to understand the interplay between the host a ...
CURRENT BIOLOGY LTD2021A Nanoscaffolded Spike-RBD Vaccine Provides Protection against SARS-CoV-2 with Minimal Anti-Scaffold Response
David Hacker, Bruno Emanuel Ferreira De Sousa Correia, Florence Pojer, Kelvin Ka Ching Lau
The response of the adaptive immune system is augmented by multimeric presentation of a specific antigen, resembling viral particles. Several vaccines have been designed based on natural or designed protein scaffolds, which exhibited a potent adaptive imm ...
2021