Optimality principles for the analysis of biological processes across scales: From enzyme kinetics to microbiome dynamics
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Math. description of metabolic systems allows the calcn. of the expected responses of metab. to genetic modifications and the identifications of the most promising targets for metabolic engineering. Metabolic control anal. (MCA) provides such a description ...
During the last decade the field of computational chem. has experienced an enormous progress. Due to the exponential increase in computer power and the development of new computational methods it has now become possible to treat many complex chem. and biol ...
A review with many refs. The recent development of two math. frameworks for the anal. and design of metabolic systems is reviewed here with many refs. Both frameworks employ a (log)linear kinetic metabolic model that is constructed making direct, explicit ...
A prototype kinetic model of bacterial glycolysis is formulated and a minimal set of assumptions is postulated that allows the formulation of an approx. math. model. To establish a baseline for future investigations of more complicated situations, it is as ...
