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Supercritical carbon dioxide processing of poly--lactide (PLLA)/hydroxyapatite (nHA) nanocomposites was investigated as a means to prepare foams suitable as scaffolds in bone tissue engineering applications. For given foaming parameters, addition of nHA to ...
The primary stability of cementless femoral components is crucial for the long-term success of total hip arthroplasty. We know that the healing phase after surgery is a complex biological process, which is affected by the mechanical environment. Implant lo ...
There is increasing evidence that mechanical stimulation affects the fate of tissue engineering scaffolds. In clinical situations, it is critical to accelerate bone formation inside the scaffold to reduce the recovery time and increase the chance of succes ...
The goal of this study was to investigate if the preparation of implantation site has an impact on bone formation inside tissue engineering scaffolds. For this purpose, two different drilling techniques were used to create a hole in distal femurs of rats b ...
After a fracture, fixing a plate to a broken bone can be problematic if the bone suffers of osteoporosis. In order to find a solution to increase bone density around the plate screws, one solution is to insert a drug-delivering bone plug that inhibits bone ...
Background: Local bisphosphonate delivery may be a solution to prevent periprosthetic bone loss and improve orthopedic implants fixation. In load-bearing implants, periprosthetic bone is exposed to high mechanical demands, which in normal conditions induce ...
Auxetic materials expand when stretched, and shrink when compressed. This is the result of a negative Poisson's ratio ν. Isotropic configurations with ν≈−1 have been designed and are expected to provide increased shear stiffness G. This assumes that Young' ...
Modification of bone implant materials with biofunctional surfaces that facilitate osteoblast adhesion and promote matrix mineralization is an attractive strategy to improve osseointegration. This manuscript discusses the preparation and properties of RGD ...
The research work reported in this dissertation is aimed to develop efficient and stable numerical schemes in order to obtain accurate numerical solution for viscoelastic fluid flows within the spectral element context. The present research consists in the ...
Background: The primary stability of cancellous screw is difficult to obtain in bone of compromised quality and failure of screw fixation is common. To overcome this problem, it is proposed to locally deliver bisphosphonate from the screw An in vivo valida ...