New access to long-chain polyketides and spiroketals by umpolung of electron rich dienes with sulfur dioxide

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Publications associées (31)

Low‐Volatility Vapors and New Particle Formation Over the Southern Ocean During the Antarctic Circumnavigation Expedition

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During summer, the Southern Ocean is largely unaffected by anthropogenic emissions, which makes this region an ideal place to investigate marine natural aerosol sources and processes. A better understanding of natural aerosol is key to constrain the preind ...

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New Vinylation and Alkynylation Strategies with Hypervalent Iodine Reagents and Diazo Compounds

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The development of a sequential copper-catalyzed oxy-alkynylation/intramolecular [4+2] cycloaddition of allenes and arenes was investigated at first. This one-pot protocol allowed the construction of complex polycylic architectures with high efficiency fro ...

EPFL2021

Diamine Synthesis via the Nitrogen-Directed Azidation of sigma- and pi-C-C Bonds

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Diamines are essential building blocks for the synthesis of agrochemicals, drugs, and organic materials, yet their synthesis remains challenging, as both nitrogens need to be differentiated and diverse substitution patterns (1,2, 1,3, or 1,4) are required. ...

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Methods for the generation of large combinatorial macrocycle libraries

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Macrocycles are an attractive class of molecules due to their good binding properties and yet rather small size that allows, in many cases, crossing membranes to reach intracellular targets. In comparison to classical small molecule drugs, macrocycles are ...

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Enantioselective Total Synthesis of (+)-Alstilobanine C, (+)-Undulifoline, and (-)-Alpneumine H

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We report herein the enantioselective total synthesis of three monoterpene indole alkaloids, namely, (+)-alstilobanine C, (+)-undulifoline, and (-)-alpneumine H. The key features of our synthesis include: a) introduction of chirality via enantioselective d ...

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Natural Product Synthesis Enabled by Domino Processes Incorporating a 1,2-Rearrangement Step

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The art of natural product total synthesis is closely associated with two major determinants: the development/application of novel chemical reactions and the innovation in strategic use of classic organic reactions. While purposely seeking/applying a new s ...

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Iodic acid, sulfuric acid and methanesulfonic acid collected during the Arctic Ocean 2018 expedition

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Measurements of iodic acid, sulfuric acid and methanesulfonic acid concentration in the gas phase obtained with a nitrate chemical ionization mass spectrometer (we used an APi-TOF mass spectrometer produced by Tofwerk AG coupled with a Chemical ionization ...

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Active sulfur cycling in the terrestrial deep subsurface

Rizlan Bernier-Latmani, Manon Frutschi, Emma Bell, Chen Qian

The deep terrestrial subsurface remains an environment where there is limited understanding of the extant microbial metabolisms. At Olkiluoto, Finland, a deep geological repository is under construction for the final storage of spent nuclear fuel. It is th ...

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Frequent new particle formation over the high Arctic pack ice by enhanced iodine emissions

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In the central Arctic Ocean the formation of clouds and their properties are sensitive to the availability of cloud condensation nuclei (CCN). The vapors responsible for new particle formation (NPF), potentially leading to CCN, have remained unidentified s ...

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Evaluation of materials for iodine and technetium immobilization through sorption and redox-driven processes

Wendy Lee Queen, Daniel Teav Sun

Radioactive iodine-129 (I-129) and technetium-99 (Tc-9(9)) pose a risk to groundwater due to their long half-lives, toxicity, and high environmental mobility. Based on literature reviewed in Moore et al. (2019) and Pearce et aL (2019), natural and engineer ...

ELSEVIER2020

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Low‐Volatility Vapors and New Particle Formation Over the Southern Ocean During the Antarctic Circumnavigation Expedition

Julia Schmale, Andrea Baccarini, Robin Lewis Modini

2021