Investigating Crosstalk Among PTMs Provides Novel Insight Into the Structural Basis Underlying the Differential Effects of Nt17 PTMs on Mutant Httex1 Aggregation

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Euclid preparation: XXVIII. Forecasts for ten different higher-order weak lensing statistics

Frédéric Courbin, Gianluca Castignani, Austin Chandler Peel, Jean-Luc Starck, Maurizio Martinelli, Yi Wang, Richard Massey, Fabio Finelli, Marcello Farina

Recent cosmic shear studies have shown that higher-order statistics (HOS) developed by independent teams now outperform standard two-point estimators in terms of statistical precision thanks to their sensitivity to the non-Gaussian features of large-scale ...

EDP SCIENCES S A2023

Secondary structure of the human mitochondrial genome affects formation of deletions

Jacques Fellay, Konstantin Popadin

BackgroundAging in postmitotic tissues is associated with clonal expansion of somatic mitochondrial deletions, the origin of which is not well understood. Such deletions are often flanked by direct nucleotide repeats, but this alone does not fully explain ...

BMC2023

Removing Algorithmic Discrimination (With Minimal Individual Error)

Rachid Guerraoui, El Mahdi El Mhamdi, Alexandre David Olivier Maurer, Le Nguyen Hoang

We address for the first time the problem of correcting group discriminations within a score function, while minimizing the individual error. Each group is described by a probability density function on the set of profiles. We first solve the problem analy ...

2022

Feature distribution learning by passive exposure

David Pascucci, Gizay Ceylan

Humans can rapidly estimate the statistical properties of groups of stimuli, including their average and variability. But recent studies of so-called Feature Distribution Learning (FDL) have shown that observers can quickly learn even more complex aspects ...

2022

Epigenetic plasticity as a signature for memory allocation

Giulia Santoni

Long-lasting memories are stored in a small set of neurons scattered throughout the brain, so-called engram cells. To define a stable engram each region of the brain involved in memory storage recruits between 5 and 20 percent of excitatory neurons. In par ...

EPFL2022

TOCOSMO VIII. A key test of systematics in the hierarchical method of time-delay cosmography

Frédéric Courbin

The largest source of systematic errors in the time-delay cosmography method likely arises from the lens model mass distribution, where an inaccurate choice of model could in principle bias the value of H-0. A Bayesian hierarchical framework has been propo ...

EDP SCIENCES S A2022

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