On-chip non-invasive voltage clamp on Xenopus oocytes

In order to improve the throughput of the traditional “Two Electrode Voltage Clamp” (TEVC) measurements on Xenopus oocytes, we present here a chip-based non-invasive technique for the measurement of ion channels activity. We focus especially on the integration of the electrical measurement site into a microfluidic structure, allowing rapid exchange of various small-volume solutions.