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A machining process based on Electro Discharge Machining (EDM) has been developed and allows producing flexible and low-cost tweezers-like grippers or grippers shaped for a specific application. It can be easily included in a micromanipulation setup and re ...
For better understanding of genetic mechanisms underlying clinical observations, it is interesting to determine which genes and clinical traits are interrelated. In the last few years a consistent amount of research in genomics has been done concerning cor ...
With a gene required for each phenotypic trait, direct genetic encodings may show poor scalability to increasing phenotype length. Developmental systems may alleviate this problem by providing more efficient indirect genotype to phenotype mappings. A novel ...
The availability of many high-quality genome-wide expression datasets has provided an exciting and unique opportunity to better understand the molecular etiology of Huntington's disease. Combining this knowledge with other aspects of huntingtin biology and ...
We consider the problem of learning dynamical models of genetic regulatory networks from time-lapse measurements of gene expression. In our previous work [Porreca et al,Bioinformatics,2010], we described a method for the structural and parametric identific ...
Copy-number variants (CNVs) form an abundant class of genetic variation with a presumed widespread impact on individual traits. While recent advances, such as the population-scale sequencing of human genomes, facilitated the fine-scale mapping of CNVs, the ...
The developmental regulation of vertebrate Hox gene transcription relies on the interplay between local and long-range controls. To study this complex genomic organization, we designed a strategy combining meiotic and targeted recombinations to induce larg ...
Bio-inspired electronic circuits have the potential to address some of the shortcomings of conventional electronic circuits, such as lack of applicability to ill-defined problems, of robustness, or of adaptivity to unexpectedly changing environments. Bio-i ...
This paper describes a new evolutionary mechanism developed specifically for cellular circuits. Called morphogenetic system, it is inspired by the mechanisms of gene expression and cell differentiation found in living organisms. It will be used as the phyl ...
Evolving large phenotypes remains nowadays a problem due to the combinatorial explosion of the search space. Seeking better scalability and inspired by the development of biological systems several indirect genetic encodings have been proposed. Here two di ...
