Multi-cellular development: is there scalability and robustness to gain?
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The genetic encoding of polypeptides with biological display systems enables the facile generation and screening of very large combinatorial libraries of molecules. By post-translationally modifying the encoded polypeptides, chemically and structurally mor ...
Many different methods exist for pattern detection in gene expression data. In contrast to classical methods, biclustering has the ability to cluster a group of genes together with a group of conditions (replicates, set of patients, or drug compounds). How ...
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Let G = (V, E) be a graph with vertex set V and edge set E. The k-coloring problem is to assign a color (a number chosen in {1, ..., k}) to each vertex of G so that no edge has both endpoints with the same color. We propose a new local search methodology, ...
Being in the layer at the interface of the body with the outside world, keratinocyte stem cells constantly adapt and respond to environmental cues such as temperature and oxygen. However, until now, experiments involving temperature have only examined cold ...
System-level design decisions such as HW/SW partitioning, target architecture selection and scheduler selection are some of the main concerns of current complex system-on-chip (SOC) designs. In this paper, a novel window-based heuristic is proposed that ad ...
For better understanding of genetic mechanisms underlying clinical observations, it is interesting to determine which genes and clinical traits are interrelated. In the last few years a consistent amount of research in genomics has been done concerning cor ...
The expression of genes is controlled by regulatory networks, which perform fundamental information processing and control mechanisms in a cell. Unraveling and modelling these networks will be indispensable to gain a systems-level understanding of biologic ...
Bio-inspired electronic circuits have the potential to address some of the shortcomings of conventional electronic circuits, such as lack of applicability to ill-defined problems, of robustness, or of adaptivity to unexpectedly changing environments. Bio-i ...
With a gene required for each phenotypic trait, direct genetic encodings may show poor scalability to increasing phenotype length. Developmental systems may alleviate this problem by providing more efficient indirect genotype to phenotype mappings. A novel ...