Optimized methods for the enzymatic ligation of oligoribonucleotides and analogues

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Decoding Chromatin Ubiquitylation: A Chemical Biology Perspective

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Since Strahl and Allis proposed the "language of covalent histone modifications", a host of experimental studies have shed light on the different facets of chromatin regulation by epigenetic mechanisms. Initially proposed as a concept for controlling gene ...

Academic Press Ltd- Elsevier Science Ltd2024

Modeling and optimization of PCB coils for inductive power transfer systems

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The auxiliary power supply for medium voltage converters requires high insulation capability between the source and the load. Inductive power transfer technology, with an air gap between the primary and secondary coil, offers such high insulation capabilit ...

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Scalable constrained optimization

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Modern optimization is tasked with handling applications of increasingly large scale, chiefly due to the massive amounts of widely available data and the ever-growing reach of Machine Learning. Consequently, this area of research is under steady pressure t ...

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Automated Formal Verification of Software Network Functions

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Formally verifying the correctness of software is necessary to merit the trust people put in software systems. Currently, formal verification requires human effort to prove that a piece of code matches its specification and code changes to improve verifiab ...

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A method and system for optimizing design, implantation, and stimulation protocols of electrodes stimulating the nervous system

Silvestro Micera, Simone Romeni

A method for optimizing at least one of a geometry, an implantation procedure, and/or stimulation protocol of one or more electrodes for an electrical stimulation of a target structure in a nervous system of a living being by a computer device, the method ...

2024

Resolving bacterial cell biology: from replisome dynamics to cell wall synthesis

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Bacteria are ubiquitous single cellular organisms. Compared to eukaryotic cells, bacteria have two unique characteristics: the membrane-less nucleoid and the cell wall built of peptidoglycan (PG). In most bacteria, a single circular chromosome is compacted ...

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The field of protein design has made remarkable progress over the past decade. Historically, the low reliability of purely structure-based design methods limited their application, but recent strategies that combine structure-based and sequence-based calcu ...

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Degrees of Separation: A Flexible Type System for Safe Concurrency

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Data races have long been a notorious problem in concurrent programming. They are subtle to detect, and lead to non-deterministic behaviours. There has been a lot of interest in type systems that statically guarantee data race freedom. Significant progress ...

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SOMOphilic alkyne vs radical-polar crossover approaches: The full story of the azido-alkynylation of alkenes

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We report the detailed background for the discovery and development of the synthesis of homopropargylic azides by the azidoalkynylation of alkenes. Initially, a strategy involving SOMOphilic alkynes was adopted, but only resulted in a 29% yield of the desi ...

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Predicting protein interactions using geometric deep learning on protein surfaces

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In the domain of computational structural biology, predicting protein interactions based on molecular structure remains a pivotal challenge. This thesis delves into this challenge through a series of interconnected studies. The first chapter introduces th ...

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A method and system for optimizing design, implantation, and stimulation protocols of electrodes stimulating the nervous system

Silvestro Micera, Simone Romeni

2024