A small metabolic flux model to identify transient metabolic regulations in Saccharomyces cerevisiae
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Deletion mutants with either deletion of HXK2 and REG1 of the wild-type strain Saccharomyces cerevisiae CEN.PK113-7D were quant. analyzed for the impact on carbon catabolite repression and the short-term effect of the oxidative metab. Therefore, continuous ...
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In many microorganisms, flux limitations in oxidative metab. lead to the formation of overflow metabolites even under fully aerobic conditions. This can be avoided if the specific growth rate is controlled at a low enough value. This is usually accomplishe ...
In Saccharomyces cerevisiae, the genes HXK2 and REG1 are believed to play a central role in carbon catabolite repression, acting on multiple pathways in the central metab. The present study aimed at quantifying the effect of deletion of genes HXK2 or REG1, ...
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The dynamic behavior of a continuous culture of Saccharomyces cerevisiae subjected to a sudden increase in the diln. rate has been successfully modelled for anaerobic growth on glucose, and for aerobic growth on acetate, on ethanol, and on glucose. The cat ...
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