Development of a large-scale biocalorimeter to monitor and control bioprocesses
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A modified heat-flux, computer-assisted bench calorimeter is described for continuous in situ measurement of heat generated during the growth of microorganisms in submerged cultures under std. lab. conditions of temp., aeration, agitation, and pH. The calo ...
Measurements of the heat produced by Saccharomyces cerevisiae CBS 426 were used in conjunction with elemental and enthalpic balances to control fed-batch fermns. A proportional control using the ratio of carbon dioxide evolution rate to heat prodn. resulte ...
A modified bench scale calorimeter has been employed to det. the heat generated by various microbial strains growing on a range of different substrates, covering degrees of redn. from 3 to 6.13. The results are analyzed and interpreted in the light of coup ...
A novel bench-scale calorimeter, which is based on a heat-flux principle and modified to accommodate biol. reactions, was evaluated for detg. the heat evolution rate of an aerobic culture of the yeast Kluyveromyces fragilis grown on lactose. The instantane ...