Publication

Enzymatic incorporation of bioactive peptides into fibrin matrices enhances neurite extension

Publications associées (42)

First Advanced Bilayer Scaffolds for Tailored Skin Tissue Engineering Produced via Electrospinning and Melt Electrowriting

In vitro skin models are validated methods for screening cosmetics and pharmaceuticals, but still have limitations. The bilayer poly(epsilon-caprolactone) scaffold/membrane model described here overcomes some of these deficits by integrating a solution ele ...

Weinheim2024

A Novel 3D-Printed/Porous Conduit with Tunable Properties to Enhance Nerve Regeneration Over the Limiting Gap Length

Silvestro Micera, Francesco Iberite

Engineered grafts constitute an alternative to autologous transplant for repairing severe peripheral nerve injuries. However, current clinically available solutions have substantial limitations and are not suited for the repair of long nerve defects. A nov ...

WILEY2023

Improved Physiochemical Properties of Chitosan@PCL Nerve Conduits by Natural Molecule Crosslinking

Silvestro Micera

Nerve conduits may represent a valuable alternative to autograft for the regeneration of long-gap damages. However, no NCs have currently reached market approval for the regeneration of limiting gap lesions, which still represents the very bottleneck of th ...

Basel2023

Highly Efficient Cardiac Differentiation and Maintenance by Thrombin-Coagulated Fibrin Hydrogels Enriched with Decellularized Porcine Heart Extracellular Matrix

Philippe Renaud, Thomas Michael Braschler, Fatemeh Navaee

Biochemical and biophysical properties instruct cardiac tissue morphogenesis. Here, we are reporting on a blend of cardiac decellularized extracellular matrix (dECM) from porcine ventricular tissue and fibrinogen that is suitable for investigations employi ...

MDPI2023

Promising eco-friendly biomaterials for future biomedicine: Cleaner production and applications of Nanocellulose

Edgard Gnansounou

Cellulose nanomaterials are developing nowadays as a promising environmental friendlier biomaterial that can be extracted from native plant sources. These materials, because of their excellent physico-chemical and biological properties, urged much interest ...

ELSEVIER2021

Tissue Factor-Independent Coagulation Correlates with Clinical Phenotype in Factor XI Deficiency and Replacement Therapy

Christian Heinis, Vanessa Carle, Alessandro Aliotta

Background In factor XI (FXI) deficiency, bleeding cannot be predicted by routine analyses. Since FXI is involved in tissue factor (TF)-independent propagation loop of coagulation, we hypothesized that investigating the spatiotemporal separated phases of c ...

GEORG THIEME VERLAG KG2020

The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing

Matthias Lütolf, Jeffrey Alan Hubbell, Yoji Tabata, Jun Ishihara, Kazuto Fukunaga

During wound healing, the distribution, availability, and signaling of growth factors (GFs) are orchestrated by their binding to extracellular matrix components in the wound microenvironment. Extracellular matrix proteins have been shown to modulate angiog ...

AMER SOC HEMATOLOGY2019

Axon regeneration and circuit reorganization after complete spinal cord injury

Sabry Leonardo Barlatey

First human trials involving neuroprosthetic rehabilitation demonstrated recently that significant functional benefits can be achieved with lumbosacral neuromodulation and reorganized spared projections. However, complete spinal cord injuries (SCI) wholly ...

EPFL2019

Required growth facilitators propel axon regeneration across complete spinal cord injury

Grégoire Courtine, Mark Andrew Anderson, Nicholas David James, Cheng Wang, Sabry Leonardo Barlatey, Michael V. Sofroniew, Zhigang He

Transected axons fail to regrow across anatomically complete spinal cord injuries (SCI) in adults. Diverse molecules can partially facilitate or attenuate axon growth during development or after injury1,2,3, but efficient reversal of this regrowth failure ...

2018

Influencing axon regeneration after spinal cord injury

Mark Andrew Anderson

Spinal cord injury (SCI) results in a severing of axonal connections that leads to permanent sensorimotor deficits. In cases of incomplete injury, rehabilitation paradigms have been reported to be successful in improving behavioral outcome in humans with S ...

EPFL2017

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