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Fibroblast alignment under interstitial fluid flow using a novel 3-D tissue culture model

Publications associées (39)

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Mechanics is known to play a fundamental role in many cellular and developmental processes. Beyond active forces and material properties, osmotic pressure is believed to control essential cell and tissue characteristics. However, it remains very challengin ...

2023

Mechanical control of tissue shape and morphogenetic flows during vertebrate body axis elongation

Sangwoo Kim

Shaping embryonic tissues into their functional morphologies requires cells to control the physical state of the tissue in space and time. While regional variations in cellular forces or cell proliferation have been typically assumed to be the main physica ...

2021

Embryonic tissues as active foams

Sangwoo Kim

The physical state of embryonic tissues emerges from non-equilibrium, collective interactions among constituent cells. Cellular jamming, rigidity transitions and characteristics of glassy dynamics have all been observed in multicellular systems, but it is ...

2021

Deviations from conventional hydraulic fracturing simulators’ predictions are sometimes observed in the field and laboratory. This questions the basic assumptions adopted in linear hydraulic fracture mechanics (LHFM): a linear elastic solid and a simplifie ...

2018

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Rationale: The transport of interstitial fluid and solutes into lymphatic vessels is important for maintaining interstitial homeostasis and delivering antigens and soluble factors to the lymph node for immune surveillance. Transendothelial transport across ...

Lippincott Williams & Wilkins2017

The talk reviews some of the analytical results available for studying the dambreak problem. Emphasis is then given to a thorough comparison between experimental data, analytical results (lubrication theory), and numerical simulations (obtained using the s ...

2014

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Visualizing the dynamic behaviors of immune cells in living tissue has dramatically increased our understanding of how cells interact with their surroundings, contributing important insights into mechanisms of leukocyte trafficking, tumor cell invasion, an ...

Public Library of Science2013

Wiig H, Swartz MA. Interstitial Fluid and Lymph Formation and Transport: Physiological Regulation and Roles in Inflammation and Cancer. Physiol Rev 92: 1005-1060, 2012; doi: 10.1152/physrev.00037.2011.-The interstitium describes the fluid, proteins, solute ...

2012

In vitro lymphatic endothelial morphogenesis

Carolyn Yong Pullin

Cell organization into functional multicellular three-dimensional structures is a long-standing challenge. In particular, engineering of vascularized tissues requires both blood and lymphatic neovascular network formation in a simultaneous and coordinated ...

EPFL2011

Mesenchymal Stem Cells (MSC) are multipotent stem cells that are predominantly obtained from the bone marrow. These cells have a high ability to differentiate into a multitude of cell types, which are very attractive for tissue engineering and cell therapy ...

2011