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KAP1 controls endogenous retroviruses in embryonic stem cells

Publications associées (31)

Ancestral genome reconstruction enhances transposable element annotation by identifying degenerate integrants

Didier Trono, Evaristo Jose Planet Letschert, Wayo Matsushima

Growing evidence indicates that transposable elements (TEs) play important roles in evolution by providing genomes with coding and non-coding sequences. Identification of TE-derived functional elements, however, has relied on TE annotations in individual s ...

2024

Metabolically enhanced CAR T cells efficiently clear solid tumors in mice

Li Tang

Chimeric antigen receptor (CAR) T cells in the solid tumor microenvironment enter a partially dysfunctional state called T cell exhaustion. Interleukin (IL)-10-producing CAR T cells retain their metabolic fitness, resist T cell exhaustion and display unpre ...

Nature Portfolio2024

The dynamic genetic determinants of increased transcriptional divergence in spermatids

Christina Ernst

Cis-genetic effects are key determinants of transcriptional divergence in discrete tissues and cell types. However, how cis- and trans-effects act across continuous trajectories of cellular differentiation in vivo is poorly understood. Here, we quantify al ...

Nature Portfolio2024

Fluorescent fatty acid conjugates for live cell imaging of peroxisomes

Luc Reymond, Fabien Kuttler, Milena Maria Schuhmacher, Manon Sandra Bardyn, Daria Korotkova, Triana Amen

Peroxisomes are eukaryotic organelles that are essential for multiple metabolic pathways, including fatty acid oxidation, degradation of amino acids, and biosynthesis of ether lipids. Consequently, peroxisome dysfunction leads to pediatric-onset neurodegen ...

Nature Research2024

In vivo polydopamine coating of Rhodobacter sphaeroides for enhanced electron transfer

Ardemis Anoush Boghossian, Melania Reggente, Fabian Fischer

Recent advances in coupling light-harvesting microorganisms with electronic components have led to a new generation of biohybrid devices based on microbial photocatalysts. These devices are limited by the poorly conductive interface between phototrophs and ...

2024

High-throughput parallel testing of ten photoelectrochemical cells for water splitting: case study on the effects of temperature in hematite photoanodes

Sophia Haussener, Isaac Thomas Holmes-Gentle, Roberto Valenza, Franky Esteban Bedoya Lora

High-throughput testing of photoelectrochemical cells and materials under well-defined operating conditions can accelerate the discovery of new semiconducting materials, the characterization of the phenomena occurring at the semiconductor-electrolyte inter ...

Royal Soc Chemistry2024

An autologous antigen-agnostic dendritic cell therapy that forgoes antigen loading

Michele De Palma

We developed a method for generating dendritic cell progenitors (DCPs) from hematopoietic stem and progenitor cells isolated from bone marrow or blood. When engineered to express IL-12 and FLT3L, these DCPs reprogram the tumor microenvironment and elicit a ...

Nature Portfolio2024

Multimodal transcriptomic atlases of mouse spinal cord injury

Matthieu Pierre Gautier

A spinal cord injury (SCI) triggers a cascade of molecular and cellular responses involving inflammatory cell infiltration and cytokine release, apoptosis, demyelination, excitotoxicity, ischemia, and the formation of a fibrotic scar surrounded by an astro ...

EPFL2024

Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development

Sangwoo Kim, Pengfei Xu

Localized sources of morphogens, called signalling centres, play a fundamental role in coordinating tissue growth and cell fate specification during organogenesis. However, how these signalling centres are established in tissues during embryonic developmen ...

Nature Portfolio2024

KAP1 controls endogenous retroviruses in embryonic stem cells

Ancestral genome reconstruction enhances transposable element annotation by identifying degenerate integrants

Metabolically enhanced CAR T cells efficiently clear solid tumors in mice

The dynamic genetic determinants of increased transcriptional divergence in spermatids

Fluorescent fatty acid conjugates for live cell imaging of peroxisomes

In vivo polydopamine coating of Rhodobacter sphaeroides for enhanced electron transfer

High-throughput parallel testing of ten photoelectrochemical cells for water splitting: case study on the effects of temperature in hematite photoanodes

An autologous antigen-agnostic dendritic cell therapy that forgoes antigen loading

Multimodal transcriptomic atlases of mouse spinal cord injury

Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development

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Ancestral genome reconstruction enhances transposable element annotation by identifying degenerate integrants

Metabolically enhanced CAR T cells efficiently clear solid tumors in mice

The dynamic genetic determinants of increased transcriptional divergence in spermatids

Fluorescent fatty acid conjugates for live cell imaging of peroxisomes

In vivo polydopamine coating of Rhodobacter sphaeroides for enhanced electron transfer

High-throughput parallel testing of ten photoelectrochemical cells for water splitting: case study on the effects of temperature in hematite photoanodes

An autologous antigen-agnostic dendritic cell therapy that forgoes antigen loading

Multimodal transcriptomic atlases of mouse spinal cord injury

Revealing chromatin-specific functions of histone deacylases

Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development

Revealing chromatin-specific functions of histone deacylases