Altered neocortical microcircuitry in the valproic acid rat model of autism
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The aim of this study is to contribute to understand the physiology of the Olfactory System through detailed microcircuit investigation, adopting advanced electrophysiological and anatomical techniques. Multiple patch clamp recordings allow understanding t ...
Interactions among neurons can take place in a wide variety of forms. It is the goal of this thesis to investigate the properties and implications of a number of these interactions that we believe are relevant for information processing in the brain. Neuro ...
The mammalian neocortex is one of the most complex brain areas, integrating all sensory modalities and allowing the animal to perform high level cognitive operations. Despite some cytoarchitectural specializations, the general neocortical structure is rema ...
The prevalence of autism, a neurodevelopmental condition resulting from genetic and environmental causes, has increased dramatically during the last decade. Among the potential environmental factors, hyperserotonemia during pregnancy and its effect on brai ...
This study is part of a long term study on a male rat model of peripubertal stress in the Laboratory of Behavioural Genetics that shows increase aggressive behaviours against their partners. We are using here these rats in order to create a female rat mode ...
Autism covers a wide spectrum of disorders for which there are many views, hypotheses and theories. Here we propose a unifying theory of autism, the Intense World Theory. The proposed neuropathology is hyper-functioning of local neural microcircuits, best ...
A single intra-peritoneal injection of valproic acid (VPA) on embryonic day (ED) 11.5 to pregnant rats has been shown to produce severe autistic-like symptoms in the offspring. Previous studies showed that the microcircuitry is hyperreactive due to hyperco ...
Apraxia is a poorly understood disorder of voluntary movement that is not due to basic sensory, motor or cognitive deficits. We conducted a study on the imitation of meaningless gestures in apraxic patients with left fronto-temporo-parietal lesions. In a f ...
The general structure of the mammalian neocortex is remarkably similar across different cortical areas. Despite certain cytoarchitectural specializations and deviations from the general blueprint, the principal organization of the neocortex is relatively u ...
Motor dysfunction, cognitive impairment, and regional cortical atrophy indicate cerebral cortical involvement in Huntington disease (HD). To address the hypothesis that abnormal corticostriatal connectivity arises from polyglutamine-related alterations in ...