Post-training administration of a synthetic peptide ligand of the neural cell adhesion molecule, C3d, attenuates long-term expression of contextual fear conditioning
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Traumatic events generate some of the most enduring forms of memories. Despite the elevated lifetime prevalence of anxiety disorders, effective strategies to attenuate long-term traumatic memories are scarce. The most efficacious treatments to diminish rec ...
Our brain has the capacity to analyze a visual scene in a split second, to learn how to play an instrument, and to remember events, faces and concepts. Neurons underlie all of these diverse functions. Neurons, cells within the brain that generate and trans ...
Reward mediates the acquisition and long-term retention of procedural skills in humans. Yet, learning under rewarded conditions is highly variable across individuals and the mechanisms that determine interindividual variability in rewarded learning are not ...
Nectins are cell adhesion molecules that are widely expressed in the brain. Nectin expression shows a dynamic spatiotemporal regulation, playing a role in neural migratory processes during development. Nectin-1 and nectin-3 and their heterophilic trans-int ...
We show that memory can be encoded in a model amorphous solid subjected to athermal oscillatory shear deformations, and in an analogous spin model with disordered interactions, sharing the feature of a deformable energy landscape. When these systems are su ...
The brain has very high energy demands that are mainly met by the circulating blood glucose to ensure its proper functioning. Thus, it is not surprising that though the human brain weighs only 2- 3% of the body weight, it consumes approximately 25% of tota ...
How to attenuate traumatic memories has long been the focus of intensive research efforts, as traumatic memories are extremely persistent and heavily impinge on the quality of life. Despite the fact that traumatic memories are often not readily amenable to ...
Down syndrome (DS) patients exhibit abnormalities of hippocampal-dependent explicit memory, a feature that is replicated in relevant mouse models of the disease. Adult hippocampal neurogenesis, which is impaired in DS and other neuropsychiatric diseases, p ...
Travel times are fundamental catchment descriptors that blend key information about storage, geochemistry, flow pathways and sources of water into a coherent mathematical framework. Here we analyze travel time distributions (TTDs) (and related attributes) ...
We present the short-term noise budget and metro-logical studies on the medium-to long-term stability of our Rb standard. Our clock exhibits a short-term stability of ∼ 1.4×10-13 τ-1/2. The dependance of microwave power shift on light intensity, and the po ...
