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Chronic restraint stress induces changes in synapse morphology in stratum lacunosum-moleculare CA1 rat hippocampus: a stereological and three-dimensional ultrastructural study

Publications associées (37)

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Memory formation and recall in recurrent spiking neural networks

Friedemann Zenke

Our brain has the capacity to analyze a visual scene in a split second, to learn how to play an instrument, and to remember events, faces and concepts. Neurons underlie all of these diverse functions. Neurons, cells within the brain that generate and trans ...

EPFL2014

Modifications of synaptic efficacies are considered essential for learning and memory. However, it is not known how the underlying functional components of synaptic transmission change over long time scales. To address this question, we studied cortical sy ...

Soc Neuroscience2013

The cortex must maintain balanced levels of neural activity to correctly integrate inputs and to provide contextually meaningful outputs. Neuronal excitation is counterbalanced by various forms of inhibition such as spike frequency adaptation, short- and l ...

EPFL2013

Facilitation of AMPA receptor synaptic delivery as a molecular mechanism for cognitive enhancement

Maria del Carmen Sandi Perez, Erika Myrna Borcel Novoa, Lidia Alonso-Nanclares

Cell adhesion molecules and downstream growth factor-dependent signaling are critical for brain development and synaptic plasticity, and they have been linked to cognitive function in adult animals. We have previously developed a mimetic peptide (FGL) from ...

2012

Neuronal theories of neurodevelopmental disorders (NDDs) of autism and mental retardation propose that abnormal connectivity underlies deficits in attentional processing. We tested this theory by studying unitary synaptic connections between layer 5 pyrami ...

Oxford University Press2012

Phosphoinositide-3-kinase activation controls synaptogenesis and spinogenesis in hippocampal neurons

Maria del Carmen Sandi Perez

The possibility of changing the number of synapses may be an important asset in the treatment of neurological diseases. In this context, the synaptogenic role of the phosphoinositide-3-kinase (PI3K) signaling cascade has been previously demonstrated in Dro ...

Society for Neuroscience2011

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The key roles played by the neural cell adhesion molecule (NCAM) in plasticity and cognition underscore this membrane protein as a relevant target to develop cognitive-enhancing drugs. However, NCAM is a structurally and functionally complex molecule with ...

Public Library of Science2011

Emergent Properties of in silico Synaptic Transmission in a Model of the Rat Neocortical Column

Srikanth Ramaswamy

The cerebral cortex occupies nearly 80% of the entire volume of the mammalian brain and is thought to subserve higher cognitive functions like memory, attention and sensory perception. The neocortex is the newest part in the evolution of the cerebral corte ...

EPFL2011

Spike-timing dependent plasticity

Wulfram Gerstner

Spike Timing Dependent Plasticity (STDP) is a temporally asymmetric form of Hebbian learning induced by tight temporal correlations between the spikes of pre- and postsynaptic neurons. As with other forms of synaptic plasticity, it is widely believed that ...

2010

Structure and function of the olfactory bulb microcircuit

Michele Pignatelli

The aim of this study is to contribute to understand the physiology of the Olfactory System through detailed microcircuit investigation, adopting advanced electrophysiological and anatomical techniques. Multiple patch clamp recordings allow understanding t ...

EPFL2009