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Transcriptional and post-transcriptional regulation of endothelin-1 gene by shear stress

Publications associées (29)

Cis-regulatory effect of HPV integration is constrained by host chromatin architecture in cervical cancers

Human papillomavirus (HPV) infections are the primary drivers of cervical cancers, and often HPV DNA gets integrated into the host genome. Although the oncogenic impact of HPV encoded genes is relatively well known, the cis-regulatory effect of integrated ...

Wiley2023

Upregulation of the ERR γ-VDAC1 axis underlies the molecular pathogenesis of pancreatitis

Johan Auwerx, Changmyung Oh, Jiale Wang

Emerging evidence suggest that transcription factors play multiple roles in the development of pancreatitis, a necroinflammatory condition lacking specific therapy. Estrogen-related receptor γ (ERRγ), a pleiotropic transcription factor, has been reported t ...

National Academy of Sciences2023

Shearing and opening of a pre-existing discontinuity in response to fluid injection

Brice Tanguy Alphonse Lecampion, Alexis Alejandro Sáez Uribe, Ankit Gupta

We investigate the fluid-driven growth of a shear crack along a frictional discontinuity and its transition to hydraulic fracturing (sometimes referred to as hydraulic jacking) under plane-strain conditions. We focus on the case of a constant friction coef ...

2023

Solids that are also liquids: elastic tensors of superionic materials

Nicola Marzari, Tommaso Chiarotti, Giuliana Materzanini

Superionics are fascinating materials displaying both solid- and liquid-like characteristics: as solids, they respond elastically to shear stress; as liquids, they display fast-ion diffusion at normal conditions. In addition to such scientific interest, su ...

NATURE PORTFOLIO2023

Diverse cell-specific patterns of alternative polyadenylation in Drosophila

Bart Deplancke, Sandy Lee

Most genes in higher eukaryotes express isoforms with distinct 3' untranslated regions (3' UTRs), generated by alternative polyadenylation (APA). Since 3' UTRs are predominant locations of post-transcriptional regulation, APA can render such programs condi ...

Nature Portfolio2022

Systematic analysis of low-affinity transcription factor binding site clusters in vitro and in vivo establishes their functional relevance

Sebastian Maerkl, Shiyu Cheng, Ivan Istomin, Maria Lopez Malo, Amir Shahein, Evan James Olson

Binding to binding site clusters has yet to be characterized in depth, and the functional relevance of low-affinity clusters remains uncertain. We characterized transcription factor binding to low-affinity clusters in vitro and found that transcription fac ...

Nature Portfolio2022

Essential role of Cp190 in physical and regulatory boundary formation

Nicolas Jean Philippe Guex, Julien Dorier, Christian Iseli

Boundaries in animal genomes delimit contact domains with enhanced internal contact frequencies and have debated functions in limiting regulatory cross-talk between domains and guiding enhancers to target promoters. Most mammalian boundaries form by stalli ...

2022

KRAB zinc-finger proteins and their transposable element targets: between antagonism and cooperation

Jonas Caspar De Tribolet-Hardy

There are 377 Krüppel-associated box (KRAB) domain-containing zinc finger proteins (KZFPs) in the human genome, making them the largest family of transcription factors. KZFPs are defined by a N-terminal KRAB domain and several zinc-finger domains arranged ...

EPFL2022

Transcriptional and post-transcriptional regulation of endothelin-1 gene by shear stress

Cis-regulatory effect of HPV integration is constrained by host chromatin architecture in cervical cancers

Upregulation of the ERR γ-VDAC1 axis underlies the molecular pathogenesis of pancreatitis

Shearing and opening of a pre-existing discontinuity in response to fluid injection

Solids that are also liquids: elastic tensors of superionic materials

Diverse cell-specific patterns of alternative polyadenylation in Drosophila

Systematic analysis of low-affinity transcription factor binding site clusters in vitro and in vivo establishes their functional relevance

Essential role of Cp190 in physical and regulatory boundary formation

KRAB zinc-finger proteins and their transposable element targets: between antagonism and cooperation

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Cis-regulatory effect of HPV integration is constrained by host chromatin architecture in cervical cancers

Upregulation of the ERR γ-VDAC1 axis underlies the molecular pathogenesis of pancreatitis

Shearing and opening of a pre-existing discontinuity in response to fluid injection

Solids that are also liquids: elastic tensors of superionic materials

Diverse cell-specific patterns of alternative polyadenylation in Drosophila

Systematic analysis of low-affinity transcription factor binding site clusters in vitro and in vivo establishes their functional relevance

Essential role of Cp190 in physical and regulatory boundary formation

KRAB zinc-finger proteins and their transposable element targets: between antagonism and cooperation

Transposable elements contribute to the spatiotemporal microRNA landscape in human brain development

Transposable elements contribute to the spatiotemporal microRNA landscape in human brain development